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beta-Estradiol, 99% (dry wt.), ca 3% water, Thermo Scientific Chemicals
Description
β-Estradiol is the major estrogen secreted by the premenopausal ovary. It acts as an estrogenic hormone receptor (ER) agonist and activator of PI 3-kinase. Further, it is used in the treatment of infertility in women, prostate cancer and breast cancer. It is also employed as an agent of stimulating female puberty induction, as in the treatment of delayed puberty caused by hypogonadism or Turner's syndrome. In addition to this, it is used as part of the hormone replacement therapy for transgender women.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
β-Estradiol is the major estrogen secreted by the premenopausal ovary. It acts as an estrogenic hormone receptor (ER) agonist and activator of PI 3-kinase. Further, it is used in the treatment of infertility in women, prostate cancer and breast cancer. It is also employed as an agent of stimulating female puberty induction, as in the treatment of delayed puberty caused by hypogonadism or Turner′s syndrome. In addition to this, it is used as part of the hormone replacement therapy for transgender women.
Solubility
Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.
Notes
Incompatible with strong oxidizing agents.
Specifications
| Melting Point | 175°C to 178°C |
| Quantity | 1 g |
| Beilstein | 1914275 |
| Merck Index | 14,3703 |
| Solubility Information | Soluble in dimethyl sulfoxide,ethanol ,water,phosphate buffer saline,dimethyl formamide,acetone,dioxane and alkali hydroxides. Slightly soluble in vegetable oils. |
| Optical Rotation | +79° (c=1 in Dioxane) |
| Formula Weight | 272.39 |
| Percent Purity | 99% |
| Assay | (dry wt.), ≈3% water |
| Chemical Name or Material | beta-Estradiol |
Safety and Handling
| Hazard Category | H350-H361fd-H362-H373 |
| Hazard Statement | GHS H Statement H350-H360 May cause cancer. May damage fertility or the unborn child. |
| Precautionary Statement | P201-P202-P260-P263-P264b-P270-P271-P281-P304+P340-P308+P313-P501c |
| EINECSNumber | 200-023-8 |
| RTECSNumber | KG2975000 |
| TSCA | No |
| Recommended Storage | Ambient temperatures |
RUO – Research Use Only
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