Benzyl carbazate, 98+%, Thermo Scientific Chemicals

Description

Benzyl carbazate is used as a reagent for preparation of benzyloxycarbonyl (Z, Cbz) hydrazides of carboxylic acids, particularly N-protected amino acids. Subsequent hydrogenolysis gives the hydrazide which can be converted to the azide for coupling with a further amino acid residue by the azide method. It is also used in the preparation of simple acyl or sulfonyl hydrazides avoiding diacylation.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Benzyl carbazate is used as a reagent for preparation of benzyloxycarbonyl (Z, Cbz) hydrazides of carboxylic acids, particularly N-protected amino acids. Subsequent hydrogenolysis gives the hydrazide which can be converted to the azide for coupling with a further amino acid residue by the azide method. It is also used in the preparation of simple acyl or sulfonyl hydrazides avoiding diacylation.

Solubility
Soluble in water (slightly), methanol and DMSO.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Handle under inert gas. Protect from moisture. Incompatible with strong oxidizing agents.

Specifications

• Melting Point: 66°C to 70°C
• Quantity: 100 g
• Beilstein: 1952982
• Solubility Information: Soluble in water (slightly),methanol and DMSO.
• Formula Weight: 166.18
• Percent Purity: ≥98%
• Chemical Name or Material: Benzyl carbazate

Safety and Handling

Hazard Category	Danger
Hazard Statement	GHS H Statement H318-H335-H315 Causes serious eye damage. May cause respiratory irritation. Causes skin irritation.
Precautionary Statement	GHS P Statement P261-P280-P305+P351+P338-P304+P340-P405-P501a Avoid breathing dust/fume/gas/mist/vapors/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.
EINECSNumber	226-230-3
RTECSNumber	MV1724950
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only