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  8. 174310

Bay 11-7085, Tocris Bioscience™

Catalog No. 174310
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Irreversible inhibitor of TNF-α-induced IκBα phosphorylation

Irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation (IC50 ∽ 10 μM); leads to decreased NF-κB and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo.

Chemical Identifiers

CAS 196309-76-9
Molecular Formula C13H15NO2S
Molecular Weight (g/mol) 249.328
InChI Key VHKZGNPOHPFPER-ONNFQVAWSA-N
Synonym e-3-4-tert-butylphenylsulfonyl acrylonitrile, e-3-4-tert-butyl phenyl sulfonyl acrylonitrile, e-3-4-t-butylphenylsulfonyl-2-propenenitrile, e-3-4-tert-butylphenyl sulfonylprop-2-enenitrile, e 3-4-t-butylphenyl sulfonyl-2-propenenitrile, 2-propenenitrile, 3-4-1,1-dimethylethyl phenyl sulfonyl-, 2e, 2e-3-4-tert-butylbenzenesulfonyl prop-2-enenitrile, bay hplc , solid, e-3-4-tert-butyl-benzenesulfonyl-acrylonitrile, e-3-4-tert-butylphenyl sulfonyl-2-propenenitrile
PubChem CID 5353432
IUPAC Name (E)-3-(4-tert-butylphenyl)sulfonylprop-2-enenitrile
SMILES CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)C=CC#N

Specifications

Quantity 10 mg
Formula Weight 249.33
Percent Purity >99%
Chemical Name or Material Bay 11-7085

Safety and Handling

Recommended Storage Store at +4°C
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