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ARRY 520 trifluoroacetate, Tocris Bioscience™
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Quantity:
10 mg
Description
Potent kinesin spindle protein (KSP) inhibitor (IC50 = 6 nM); selective for KSP over >250 other receptors and kinases at a concentration of 10 μM. Displays robust antitumor activity in bortezomib-resistant xenografts either alone or in combination with bortezomib. Induces degradation of Mcl-1; exhibits comparable cytotoxic activity to taxol (Cat. No. 1097) in epithelial ovarian cancer cells. Active in vivo.
Specifications
Quantity | 10 mg |
Formula Weight | 420.48 |
Percent Purity | >98% |
Chemical Name or Material | ARRY 520 trifluoroacetate |
Safety and Handling
Recommended Storage | Store at -20°C |
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