CD45RO Mouse anti-Human, APC, Clone: UCHL1, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 559865

Catalog No. BDB559865

Description

CD45RO, a member of the CD45 family that includes CD45, CD45RA, and CD45RB, recognizes a 180-kilodalton (kd) isoform of the leucocyte common antigen (LCA). The CD45 antigen is a protein tyrosine phosphatase. In peripheral blood, the CD45RO antigen is present on approximately 40% of resting peripheral blood T lymphocytes, including the CD4+ and CD8+ subpopulations, as well as on most thymocytes and activated T lymphocytes. It is also expressed on monocytes, macrophages, and granulocytes. The CD45RO antigen is present at low density early in the T-lymphocyte maturation cycle. Upon activation by phytohemagglutinin (PHA) or alloantigen, naive T lymphocytes first acquire CD45RO and then lose CD45RA. When these activated T lymphocytes are rechallenged, the cells that exhibit a secondary response are primarily CD45RO+ , leading to the concept that CD45RO+ cells are a primed population of memory T lymphocytes.

Specifications

• Antigen: CD45RO
• Classification: Monoclonal
• Conjugate: APC
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: UCHL1
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Immunogen: Human IL-2-dependent T-cell line
• Quantity: 100 Tests
• Research Discipline: Immunology
• Target Species: Human
• Isotype: IgG2a κ