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  7. Amiloride hydrochloride dihydrate, Thermo Scientific Chemicals

Amiloride hydrochloride dihydrate, Thermo Scientific Chemicals

Catalog Number AAJ6216803
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Quantity:
1 g
5 g
17440-83-4
C6H13Cl2N7O3
302.116
MFCD00058197
LTKVFMLMEYCWMK-UHFFFAOYSA-N
amiloride hydrochloride dihydrate, modamide, nirulid, amiloride hcl, amiloride hcl dihydrate, amilorid hydrochlorid-2-wasser, unii-fzj37245uc, amiloride hydrochloride usan:usp, amiloride dihydrate hydrochloride, n-amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride dihydrate
68540
CHEBI:2640
3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;dihydrate;hydrochloride
C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.O.O.Cl
17440-83-4
C6H13Cl2N7O3
302.116
MFCD00058197
LTKVFMLMEYCWMK-UHFFFAOYSA-N
amiloride hydrochloride dihydrate, modamide, nirulid, amiloride hcl, amiloride hcl dihydrate, amilorid hydrochlorid-2-wasser, unii-fzj37245uc, amiloride hydrochloride usan:usp, amiloride dihydrate hydrochloride, n-amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride dihydrate
68540
CHEBI:2640
3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;dihydrate;hydrochloride
C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.O.O.Cl

Description

Sodium channel blocker

Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 ?M. Amiloride

  • HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.

    This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

    Applications
    Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 μM. Amiloride • HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.

    Solubility
    Soluble in water at 50mg/ml

    Notes
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.
    TRUSTED_SUSTAINABILITY
    Melting Point >240°C
    Color Yellow
    Quantity 1 g
    UN Number UN2811
    Merck Index 14,406
    Solubility Information Soluble in water at 50mg/ml
    Formula Weight 266.09
    Physical Form Powder
    Chemical Name or Material Amiloride hydrochloride dihydrate

    Safety and Handling

    Hazard Category H301
    Hazard Statement GHS H Statement
    H301
    Toxic if swallowed.
    Precautionary Statement P264b-P270-P301+P310-P330-P501c
    DOTInformation Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
    EINECSNumber 217-958-2
    RTECSNumber UQ2275500
    TSCA No
    Recommended Storage Ambient temperatures
    SDS

    RUO – Research Use Only

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