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  7. 6,7-Dihydroxycoumarin, 98+%, Thermo Scientific Chemicals

6,7-Dihydroxycoumarin, 98+%, Thermo Scientific Chemicals

Catalog Number AAA1539303
Click to view available options
Quantity:
1 g
5 g
305-01-1
C9H6O4
178.143
MFCD00006874
ILEDWLMCKZNDJK-UHFFFAOYSA-N
esculetin, 6,7-dihydroxycoumarin, aesculetin, cichorigenin, 6,7-dihydroxy-2h-chromen-2-one, cichoriin aglucon, esculatin, esculetol, esculin aglucon, esculin aglycon
5281416
CHEBI:490095
6,7-dihydroxychromen-2-one
C1=CC(=O)OC2=CC(=C(C=C21)O)O
305-01-1
C9H6O4
178.143
MFCD00006874
ILEDWLMCKZNDJK-UHFFFAOYSA-N
esculetin, 6,7-dihydroxycoumarin, aesculetin, cichorigenin, 6,7-dihydroxy-2h-chromen-2-one, cichoriin aglucon, esculatin, esculetol, esculin aglucon, esculin aglycon
5281416
CHEBI:490095
6,7-dihydroxychromen-2-one
C1=CC(=O)OC2=CC(=C(C=C21)O)O

Description

In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.

Solubility
Soluble in DMSO, DMF, diluted alkalies with blue fluorescence, and acetone. Slightly soluble in water. Insoluble in ether. Moderately soluble in Glacial acetic acid, and hot ethanol.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agents.
TRUSTED_SUSTAINABILITY
Melting Point ∼270°C (decomposition)
Quantity 1 g
Beilstein 152788
Merck Index 14,3697
Solubility Information Soluble in DMSO,DMF,diluted alkalies with blue fluorescence,and acetone. Slightly soluble in water. Insoluble in ether. Moderately soluble in Glacial acetic acid,and hot ethanol.
Formula Weight 178.15
Percent Purity ≥98%
Chemical Name or Material 6,7-Dihydroxycoumarin

Safety and Handling

Hazard Category H315-H319-H335
Hazard Statement GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Precautionary Statement P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
EINECSNumber 206-161-5
RTECSNumber GN6382500
TSCA No
Recommended Storage Keep cold
SDS

RUO – Research Use Only

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