Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Organoheterocyclic compounds
  6. Thiolactams
  7. MP215213425

4-Thiouridine, MP Biomedicals™

Catalog No. MP215213425
Click to view available options
Quantity:
25 mg

Description

Typically used to modify oligos slated for RNA or RNA-protein structural studies. 4-Thiouridine, MP Biomedicals is an anti-metabolite and a photoactivable uridine analogue used as an affinity label. It is a thiol-modified ribonucleoside in which the oxyge

4-Thiouridine is an enzyme inhibitor, generally irreversible, that is similar in structure to a particular substrate for a specific enzyme. 4-Thiouridine is typically used to modify oligos slated for RNA, or RNA-protein, structural studies.

  • A 4-thio-rU modified RNA pentamer was used to study the effect of this modification on codon-anticodon interaction when it is in the wobble position of tRNA.
  • 4-thio-rU modified RNA oligos have been used as photoaffinity probes in the role of substrate analogs for characterizing the enzyme:substrate complex of tRNA:pseudouridine-5S synthase.
  • 4-thio-rU modified oligos have been used as modules for assembling U25 small nucleolar RNAs (U25snoRNA) by ligation. These snoRNAs were used in cross-linking studies to identify which proteins assembled on them in vivo in Xenopus oocytes.
  • Because the thiol group is chemically reactive, other moieties can be conjugated at the thiol group of 4-thio-rU. Such a strategy was used to introduce spin labels to 4-thio-rU-containing RNA oligos.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 13957-31-8
Molecular Formula C9H12N2O5S
Molecular Weight (g/mol) 260.26
MDL Number MFCD00006538
InChI Key ZLOIGESWDJYCTF-XVFCMESISA-N
Synonym 4-thiouridine, thiouridine, uridine, 4-thio, 1-beta-d-ribofuranosyl-4-thiouracil, 1-2r,3r,4s,5r-3,4-dihydroxy-5-hydroxymethyl tetrahydrofuran-2-yl-4-thioxo-3,4-dihydropyrimidin-2 1h-one, 1-beta-d-ribofuranosyl-4-thioxo-3,4-dihydropyrimidin-2 1h-one, s4u, thiouridine van, uridine,4-thio, 4-thio-d-uridine
PubChem CID 3032615
ChEBI CHEBI:20480
IUPAC Name 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-sulfanylidene-1,2,3,4-tetrahydropyrimidin-2-one
SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(=S)NC1=O

Specifications

Quantity 25 mg
Solubility Information Soluble in water (20mg/mL, clear, dark yellow solution).
Formula Weight 260.3
Percent Purity ∼98%
Physical Form Powder

Safety and Handling

Recommended Storage 0°C.
WARNING: Cancer - www.P65Warnings.ca.gov
Provide Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.