3-Isobutyl-1-methylxanthine, Thermo Scientific Chemicals

Description

 

3-Isobutyl-1-methylxanthine is used in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Inhibits the growth of carcinoma cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
3-Isobutyl-1-methylxanthine is used in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction.

Specifications

Chemical Identifiers

• CAS: 28822-58-4
• Molecular Formula: C10H14N4O2
• Molecular Weight (g/mol): 222.25
• MDL Number: MFCD00005584
• InChI Key: APIXJSLKIYYUKG-UHFFFAOYSA-N
• Synonym: 3-isobutyl-1-methylxanthine, ibmx, isobutylmethylxanthine, 1-methyl-3-isobutylxanthine, methylisobutylxanthine, 3-isobutyl-1-methyl-1h-purine-2,6 3h,7h-dione, xanthine, 3-isobutyl-1-methyl, 3-isobutyl-1-methyxanthine, 1h-purine-2,6-dione, 3,7-dihydro-1-methyl-3-2-methylpropyl, methyl-isobutylxanthine
• PubChem CID: 3758
• ChEBI: CHEBI:43253
• IUPAC Name: 1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione
• SMILES: CC(C)CN1C2=C(NC=N2)C(=O)N(C)C1=O

• Melting Point: 200°C to 201°C
• Quantity: 100 mg
• Solubility Information: Soluble in ethanol.
• Formula Weight: 222.24
• Physical Form: Solid
• Chemical Name or Material: 3-Isobutyl-1-methylxanthine

Safety and Handling

Hazard Category	H302
Hazard Statement	GHS H Statement H302 Harmful if swallowed.
Precautionary Statement	P264b-P270-P301+P312-P330-P501c
EINECSNumber	249-259-3
RTECSNumber	ZD8500000
TSCA	No
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only