2-Mercapto-1-methylimidazole, 98%, Thermo Scientific Chemicals

Description

2-Mercapto-1-methylimidazole, CAS # 60-56-0, also known as methimazole, is a thyroid hormone antagonist used to study the treatment of thyroid disorders.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• 2-Mercapto-1-methylimidazole, also known as methimazole, is an antithyroid medication

• Methimazole works by inhibiting the enzyme thyroid peroxidase (TPO), which is responsible for synthesizing the thyroid hormones triiodothyronine (T3) and thyroxine (T4) from the precursor thyroglobulin

Applications

• Methimazole has been used in laboratory settings to model olfactory epithelial degeneration

• May be used to study disruptions in iodide metabolism

• Methimazole has been used in Pharmacokinetics studies in the laboratory

Specifications

Chemical Identifiers

• CAS: 60-56-0
• Molecular Formula: C4H6N2S
• Molecular Weight (g/mol): 114.17
• MDL Number: MFCD00179321
• InChI Key: PMRYVIKBURPHAH-UHFFFAOYSA-N
• Synonym: methimazole, thiamazole, 2-mercapto-1-methylimidazole, tapazole, mercazolyl, 1-methylimidazole-2-thiol, mercazole, metazolo, methimazol, thiamazol
• PubChem CID: 1349907
• ChEBI: CHEBI:50673
• IUPAC Name: 3-methyl-1H-imidazole-2-thione
• SMILES: CN1C=CNC1=S

• Melting Point: 140.0°C to 145.0°C
• Color: Cream to White
• Boiling Point: 280.0°C
• Flash Point: >100°C
• Loss on Drying: 1% (105°C, 2 hrs) max.
• Infrared Spectrum: Authentic
• Assay Percent Range: 98%
• Packaging: Glass bottle
• Quantity: 100 g
• Beilstein: 24,17
• Merck Index: 15,6043
• Solubility Information: Solubility in water: soluble. Other solubilities: soluble in ethanol and acetone,sparingly soluble in ether,petr. ether,benzene
• Formula Weight: 114.16
• Percent Purity: 98%
• Physical Form: Crystalline Powder
• Chemical Name or Material: 2-Mercapto-1-methylimidazole

Safety and Handling

Hazard Category	GHS Signal Word: Warning
Hazard Statement	GHS H Statement May cause an allergic skin reaction. Suspected of damaging fertility. Suspected of damaging the unborn child.
Precautionary Statement	GHS P Statement Wear eye protection/face protection. Use personal protective equipment as required. Avoid breathing dust/fume/gas/mist/vapors/spray. Contaminated work clothing should not be allowed out of the workplace.
EINECSNumber	200-482-4

SDS

RUO – Research Use Only