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1,1-Dimethylbiguanide hydrochloride, Thermo Scientific Chemicals
Description
1,1-Dimethylbiguanide hydrochloride is used as an antidiabetic agent, used in polycystic ovary syndrome, non-alcoholic fatty liver disease and diabetes mellitus type 2. It may also reduce weight gain in people taking atypical antipsychotics, used in a study to investigate its role in enhancing the secretions of plasma active glucagon-like peptide-1 (GLP-1) levels.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• 1,1-Dimethylbiguanide consists of two guanidines with methyl substitutions at position 1
• 1,1-Dimethylbiguanide hydrochloride inhibits complex I of the mitochondrial respiratory chain, increasing AMP and activating target genes
• 1,1-Dimethylbiguanide hydrochloride enhances insulin sensitivity and fatty acid oxidation in cells
• 1,1-Dimethylbiguanide hydrochloride may also have antineoplastic action through the mammalian target of rapamycin pathway
• It is suitable for the laboratory research of diabetes, obesity, and related metabolic disorders
• It is also useful for the laboratory study of mammalian target of rapamycin (mTOR) pathways and AMPK ratios within the cell
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Specifications
Melting Point | 218°C to 226°C |
Color | White |
Linear Formula | NH2C(=NH)NHC(=NH)N(CH3)2·HCl |
Quantity | 100 g |
Merck Index | 14,5938 |
Solubility Information | Soluble in water (50mg/ml),ethanol,and DMSO (50 mM). |
Formula Weight | 165.62 |
Physical Form | Powder |
Chemical Name or Material | 1,1-Dimethylbiguanide hydrochloride |
Safety and Handling
Hazard Category | H302-H315-H319-H335 |
Hazard Statement | GHS H Statement H302-H315-H319 Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. |
Precautionary Statement | P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c |
EINECSNumber | 214-230-6 |
RTECSNumber | DU1800000 |
TSCA | No |
Recommended Storage | Keep cold |
RUO – Research Use Only
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