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  7. 1,1-Dimethylbiguanide hydrochloride, Thermo Scientific Chemicals

1,1-Dimethylbiguanide hydrochloride, Thermo Scientific Chemicals

Catalog Number AAJ6336122
Click to view available options
Quantity:
5 g
25 g
100 g
1115-70-4
C4H12ClN5
165.63
MFCD00012582
OETHQSJEHLVLGH-UHFFFAOYSA-N
metformin hydrochloride, 1,1-dimethylbiguanide hydrochloride, metformin hcl, glucophage, riomet, diabefagos, meguan, metformin monohydrochloride, benofomin, denkaform
14219
hydrogen 1-[(diaminomethylidene)amino]-N,N-dimethylmethanimidamide chloride
[H+].[Cl-].CN(C)C(=N)N=C(N)N
1115-70-4
C4H12ClN5
165.63
MFCD00012582
OETHQSJEHLVLGH-UHFFFAOYSA-N
metformin hydrochloride, 1,1-dimethylbiguanide hydrochloride, metformin hcl, glucophage, riomet, diabefagos, meguan, metformin monohydrochloride, benofomin, denkaform
14219
hydrogen 1-[(diaminomethylidene)amino]-N,N-dimethylmethanimidamide chloride
[H+].[Cl-].CN(C)C(=N)N=C(N)N

Description

1,1-Dimethylbiguanide hydrochloride (metformin hydrochloride, CAS # 115-70-4) is the salt of methylated biguanide, a compound exhibiting anti-hyperglycemic properties.

1,1-Dimethylbiguanide hydrochloride is used as an antidiabetic agent, used in polycystic ovary syndrome, non-alcoholic fatty liver disease and diabetes mellitus type 2. It may also reduce weight gain in people taking atypical antipsychotics, used in a study to investigate its role in enhancing the secretions of plasma active glucagon-like peptide-1 (GLP-1) levels.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• 1,1-Dimethylbiguanide consists of two guanidines with methyl substitutions at position 1

• 1,1-Dimethylbiguanide hydrochloride inhibits complex I of the mitochondrial respiratory chain, increasing AMP and activating target genes

• 1,1-Dimethylbiguanide hydrochloride enhances insulin sensitivity and fatty acid oxidation in cells

• 1,1-Dimethylbiguanide hydrochloride may also have antineoplastic action through the mammalian target of rapamycin pathway

• It is suitable for the laboratory research of diabetes, obesity, and related metabolic disorders

• It is also useful for the laboratory study of mammalian target of rapamycin (mTOR) pathways and AMPK ratios within the cell

TRUSTED_SUSTAINABILITY
Melting Point 218°C to 226°C
Color White
Linear Formula NH2C(=NH)NHC(=NH)N(CH3)2·HCl
Quantity 100 g
Merck Index 14,5938
Solubility Information Soluble in water (50mg/ml),ethanol,and DMSO (50 mM).
Formula Weight 165.62
Physical Form Powder
Chemical Name or Material 1,1-Dimethylbiguanide hydrochloride

Safety and Handling

Hazard Category H302-H315-H319-H335
Hazard Statement GHS H Statement
H302-H315-H319
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
Precautionary Statement P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
EINECSNumber 214-230-6
RTECSNumber DU1800000
TSCA No
Recommended Storage Keep cold
SDS

RUO – Research Use Only

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