Hs07178285_cn

• Gene Symbol: STK4
• Assay Reference Genome Location: Chr.20:44977782 on build GRCh38
• Cytoband: 20q13.12

Target Gene Details

• Entrez Gene ID: 6789
• Gene Name: serine/threonine kinase 4
• Gene Aliases: KRS2, MST1, YSK3
• Location: Chr.20:44966474-45079977 on Build GRCh38
• Assay Gene Location: Within Intron 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
STK4	NM_006282.3			NP_006273.1
	XM_005260530.2			XP_005260587.1
	XM_005260531.3			XP_005260588.1
	XM_005260532.3			XP_005260589.1
	XM_005260533.2			XP_005260590.1
	XM_011529018.2			XP_011527320.1
	XM_011529020.2			XP_011527322.1
	XM_017028029.1			XP_016883518.1
	XM_017028030.1			XP_016883519.1
	XM_017028031.1			XP_016883520.1
	XM_017028032.1			XP_016883521.1
	XM_017028033.1			XP_016883522.1
	AB209315.1			BAD92552.1
	AK309169.1
	AK315238.1
	AL597960.1
	BC015332.1
	BC029511.1			AAH29511.1
	BC058916.1			AAH58916.1
	BC093768.1			AAH93768.1
	CR933633.1			CAI45939.1
	U18297.1			AAA83254.1
	U60207.1			AAB17262.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1056102	Chr.20:44673341 - 45636248 on Build GRCh38	Loss	MIR6812 SYS1-DBNDD2 RBPJL WFDC12 KCNK15-AS1 TOMM34 WFDC5 EPPIN YWHAB PI3 SEMG2 SEMG1 WFDC2 STK4 SDC4 WFDC6 WFDC10A SLPI RIMS4 DBNDD2 WFDC9 MATN4 WISP2 SPINT3 TP53TG5 KCNS1 SYS1 EPPIN-WFDC6 PABPC1L WFDC8 STK4-AS1 KCNK15 PIGT

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

cell morphogenesis
patterning of blood vessels
neural tube formation
positive regulation of protein phosphorylation
endocardium development
protein phosphorylation
apoptotic process
signal transduction
central nervous system development
negative regulation of cell proliferation
peptidyl-serine phosphorylation
signal transduction by protein phosphorylation
keratinocyte differentiation
positive regulation of protein binding
positive regulation of peptidyl-serine phosphorylation
hippo signaling
intracellular signal transduction
positive regulation of apoptotic process
positive regulation of fat cell differentiation
negative regulation of organ growth
protein autophosphorylation
protein stabilization
primitive hemopoiesis
cell differentiation involved in embryonic placenta development
regulation of cell differentiation involved in embryonic placenta development
positive regulation of protein serine/threonine kinase activity
negative regulation of canonical Wnt signaling pathway
hepatocyte apoptotic process
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Function(s)

magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
transcription factor binding
identical protein binding
protein homodimerization activity
protein serine/threonine kinase activator activity
protein dimerization activity