Hs07090455_cn

• Gene Symbol: DICER1
• Assay Reference Genome Location: Chr.14:95137976 on build GRCh38
• Cytoband: 14q32.13

Target Gene Details

• Entrez Gene ID: 23405
• Gene Name: dicer 1, ribonuclease III
• Gene Aliases: DCR1, Dicer, Dicer1e, HERNA, K12H4.8-LIKE, MNG1, RMSE2
• Location: Chr.14:95086228-95158010 on Build GRCh38
• Assay Gene Location: Within Intron 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DICER1	NM_001291628.1			NP_001278557.1
	NM_030621.4			NP_085124.2
	NM_177438.2			NP_803187.1
	XM_011536599.1			XP_011534901.1
	XM_011536600.2			XP_011534902.1
	XM_011536601.2			XP_011534903.1
	XM_011536602.2			XP_011534904.1
	XM_017021120.1			XP_016876609.1
	XM_017021121.1			XP_016876610.1
	XM_017021122.1			XP_016876611.1
	XM_017021123.1			XP_016876612.1
	AB023145.2			BAA76772.2
	AB028449.1			BAA78691.1
	AY845867.1			AAW31883.1
	AY845868.1			AAW31884.1
	AY929254.1			AAX18334.1
	AY929255.1			AAX18335.1
	AY929256.1			AAX18336.1
	BC150287.1
	BM152875.1

Target Gene Details

• Entrez Gene ID: 100422981
• Gene Name: microRNA 3173
• Gene Aliases: mir-3173
• Location: Chr.14:95137919-95137986 on Build GRCh38
• Assay Gene Location: Overlaps - Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MIR3173	NR_036131.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3635396	Chr.14:95103520 - 95288202 on Build GRCh38	Gain	CLMN DICER1 MIR3173 DICER1-AS1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
apoptotic DNA fragmentation
negative regulation of Schwann cell proliferation
positive regulation of Schwann cell differentiation
nerve development
production of siRNA involved in RNA interference
targeting of mRNA for destruction involved in RNA interference
gene silencing by RNA
pre-miRNA processing
positive regulation of myelination
peripheral nervous system myelin formation
conversion of ds siRNA to ss siRNA involved in RNA interference
siRNA loading onto RISC involved in RNA interference
production of miRNAs involved in gene silencing by miRNA
miRNA loading onto RISC involved in gene silencing by miRNA
conversion of ds siRNA to ss siRNA
neuron projection morphogenesis
RNA phosphodiester bond hydrolysis, endonucleolytic

Function(s)

double-stranded RNA binding
helicase activity
endoribonuclease activity
ribonuclease III activity
deoxyribonuclease I activity
protein binding
ATP binding
protein domain specific binding
siRNA binding
metal ion binding
pre-miRNA binding