Hs05987679_cn

• Gene Symbol: ITK
• Assay Reference Genome Location: Chr.5:157181733 on build GRCh38
• Cytoband: 5q33.3

Target Gene Details

• Entrez Gene ID: 3702
• Gene Name: IL2 inducible T-cell kinase
• Gene Aliases: EMT, LPFS1, LYK, PSCTK2
• Location: Chr.5:157180896-157255185 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ITK	NM_005546.3			NP_005537.3
	AB209622.1			BAD92859.1
	AK303609.1
	AK312846.1
	BC109077.2			AAI09078.1
	BC109078.1			AAI09079.1
	D13720.1			BAA02873.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3575892	Chr.5:156975204 - 157220778 on Build GRCh38	Gain	HAVCR1 MED7 FAM71B ITK HAVCR2

More Information

Additional Information:

For this assay, SNP(s) [rs138557753] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

cytokine production
NK T cell differentiation
adaptive immune response
cellular defense response
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
activation of phospholipase C activity
interferon-gamma production
interleukin-4 production
intracellular signal transduction
peptidyl-tyrosine autophosphorylation
Fc-epsilon receptor signaling pathway
T cell activation
regulation of cell proliferation
innate immune response
T cell receptor signaling pathway

Function(s)

non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
metal ion binding