Hs05576181_cn

• Gene Symbol: SREBF2
• Assay Reference Genome Location: Chr.22:41834260 on build GRCh38
• Cytoband: 22q13.2

Target Gene Details

• Entrez Gene ID: 6721
• Gene Name: sterol regulatory element binding transcription factor 2
• Gene Aliases: SREBP-2, SREBP2, bHLHd2
• Location: Chr.22:41833079-41907308 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SREBF2	NM_004599.3			NP_004590.2
	NR_103834.1
	XM_006724310.2			XP_006724373.1
	XM_011530347.1			XP_011528649.1
	XM_017028921.1			XP_016884410.1
	XM_017028922.1			XP_016884411.1
	AK299914.1
	BC051385.1
	BC051799.1			AAH51799.1
	BC056158.1			AAH56158.1
	CT841522.1			CAJ86452.1
	U02031.1			AAA50746.1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, non-DGV Variation

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
lipid metabolic process
cholesterol metabolic process
cellular response to starvation
positive regulation of cholesterol storage
positive regulation of transcription from RNA polymerase II promoter
response to low-density lipoprotein particle
cellular response to laminar fluid shear stress
regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
negative regulation of cholesterol efflux
regulation of mitophagy
positive regulation of protein targeting to mitochondrion
regulation of cholesterol homeostasis

Function(s)

C-8 sterol isomerase activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein binding
protein C-terminus binding
protein dimerization activity
E-box binding