Hs05245239_cn

• Gene Symbol: TIRAP
• Assay Reference Genome Location: Chr.11:126283605 on build GRCh38
• Cytoband: 11q24.2

Target Gene Details

• Entrez Gene ID: 114609
• Gene Name: TIR domain containing adaptor protein
• Gene Aliases: BACTS1, Mal, MyD88-2, wyatt
• Location: Chr.11:126281268-126294933 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TIRAP	NM_001039661.1			NP_001034750.1
	NM_001318776.1			NP_001305705.1
	NM_001318777.1			NP_001305706.1
	NM_148910.2			NP_683708.1
	XM_005271399.3			XP_005271456.2
	XM_011542576.2			XP_011540878.1
	XM_017017161.1			XP_016872650.1
	XM_017017162.1			XP_016872651.1
	AF378129.1			AAL05627.1
	AF410783.1			AAL05036.1
	AK124298.1
	AK313147.1
	BC032474.1			AAH32474.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv556530	Chr.11:126264724 - 126393990 on Build GRCh38	Loss	TIRAP FOXRED1 ST3GAL4-AS1 SRPRA ST3GAL4 HP11014 DCPS

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

MyD88-dependent toll-like receptor signaling pathway
inflammatory response
cell surface receptor signaling pathway
activation of NF-kappaB-inducing kinase activity
myeloid cell differentiation
positive regulation of B cell proliferation
response to lipopolysaccharide
regulation of interferon-beta production
positive regulation of interleukin-12 production
positive regulation of interleukin-15 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
positive regulation of toll-like receptor 2 signaling pathway
positive regulation of toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
positive regulation of toll-like receptor 4 signaling pathway
TIRAP-dependent toll-like receptor 4 signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of growth of symbiont in host
innate immune response
regulation of innate immune response
positive regulation of interleukin-6 biosynthetic process
positive regulation of JNK cascade
defense response to Gram-positive bacterium
positive regulation of NF-kappaB transcription factor activity
positive regulation of ERK1 and ERK2 cascade
3'-UTR-mediated mRNA stabilization
cellular response to bacterial lipopeptide
cellular response to lipoteichoic acid
positive regulation of neutrophil chemotaxis
positive regulation of protein homodimerization activity
positive regulation of chemokine (C-X-C motif) ligand 1 production
positive regulation of chemokine (C-X-C motif) ligand 2 production

Function(s)

protein kinase C binding
protein binding
phosphatidylinositol-4,5-bisphosphate binding
protein binding, bridging
Toll-like receptor 4 binding
Toll-like receptor 2 binding
protein homodimerization activity
protein heterodimerization activity