Hs05210643_cn

• Gene Symbol: TCF7L2
• Assay Reference Genome Location: Chr.10:112980188 on build GRCh38
• Cytoband: 10q25.2

Target Gene Details

• Entrez Gene ID: 6934
• Gene Name: transcription factor 7 like 2
• Gene Aliases: TCF-4, TCF4
• Location: Chr.10:112950219-113167678 on Build GRCh38
• Assay Gene Location: Within Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TCF7L2	NM_001146274.1			NP_001139746.1
	NM_001146283.1			NP_001139755.1
	NM_001146284.1			NP_001139756.1
	NM_001146285.1			NP_001139757.1
	NM_001146286.1			NP_001139758.1
	NM_001198525.1			NP_001185454.1
	NM_001198526.1			NP_001185455.1
	NM_001198527.1			NP_001185456.1
	NM_001198528.1			NP_001185457.1
	NM_001198529.1			NP_001185458.1
	NM_001198530.1			NP_001185459.1
	NM_001198531.1			NP_001185460.1
	NM_030756.4			NP_110383.2
	XM_005270071.1			XP_005270128.1
	XM_005270075.1			XP_005270132.1
	XM_005270077.1			XP_005270134.1
	XM_005270078.1			XP_005270135.1
	XM_005270079.1			XP_005270136.1
	XM_005270080.1			XP_005270137.1
	XM_005270084.1			XP_005270141.1
	XM_005270085.1			XP_005270142.1
	XM_005270086.1			XP_005270143.1
	XM_005270088.1			XP_005270145.1
	XM_005270089.1			XP_005270146.1
	XM_005270091.2			XP_005270148.1
	XM_005270092.1			XP_005270149.1
	XM_005270093.2			XP_005270150.1
	XM_005270094.2			XP_005270151.1
	XM_005270095.1			XP_005270152.1
	XM_005270096.2			XP_005270153.1
	XM_005270100.1			XP_005270157.1
	XM_005270101.2			XP_005270158.1
	XM_005270102.1			XP_005270159.1
	XM_005270103.1			XP_005270160.1
	XM_005270104.1			XP_005270161.1
	XM_011540109.1			XP_011538411.1
	XM_011540110.1			XP_011538412.1
	XM_011540111.1			XP_011538413.1
	XM_011540113.2			XP_011538415.1
	XM_011540116.1			XP_011538418.1
	XM_017016584.1			XP_016872073.1
	XM_017016585.1			XP_016872074.1
	XM_017016586.1			XP_016872075.1
	XM_017016587.1			XP_016872076.1
	XM_017016588.1			XP_016872077.1
	XM_017016589.1			XP_016872078.1
	XM_017016590.1			XP_016872079.1
	XM_017016591.1			XP_016872080.1
	XM_017016592.1			XP_016872081.1
	XM_017016593.1			XP_016872082.1
	XM_017016594.1			XP_016872083.1
	XM_017016595.1			XP_016872084.1
	XM_017016596.1			XP_016872085.1
	AB440195.1
	AB451266.1
	AK225809.1
	AK299295.1
	AK315243.1
	BC032656.1			AAH32656.1
	BX648364.1
	CR536574.1			CAG38811.1
	FJ010164.1
	FJ010165.1
	FJ010166.1
FJ010167.1
FJ010168.1
FJ010169.1
FJ010170.1
FJ010171.1
FJ010172.1
FJ010173.1
FJ010174.1
HM352838.1
HM352839.1
HM352840.1
HM352841.1
HM352842.1
HM352843.1
HM352844.1
HM352845.1
HM352846.1
HM352847.1
HM352848.1
HM352849.1
HM352850.1
HM352851.1
Y11306.2			CAA72166.2

More Information

Additional Information:

For this assay, SNP(s) [rs116425384] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, non-DGV Variation

Panther Classification:

Molecular Function -

DNA-binding transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
blood vessel development
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cell cycle arrest
Wnt signaling pathway, calcium modulating pathway
cell proliferation
response to glucose
positive regulation of heparan sulfate proteoglycan biosynthetic process
pancreas development
positive regulation of insulin secretion
positive regulation of protein binding
regulation of hormone metabolic process
glucose homeostasis
negative regulation of sequence-specific DNA binding transcription factor activity
maintenance of DNA repeat elements
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
fat cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of protein export from nucleus
myoblast fate commitment
regulation of smooth muscle cell proliferation
positive regulation of protein kinase B signaling
canonical Wnt signaling pathway
negative regulation of canonical Wnt signaling pathway
beta-catenin-TCF complex assembly
negative regulation of type B pancreatic cell apoptotic process
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II repressing transcription factor binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
transcription factor binding
protein kinase binding
nuclear hormone receptor binding
sequence-specific DNA binding
transcription regulatory region DNA binding
gamma-catenin binding
armadillo repeat domain binding