Hs05180174_cn

• Gene Symbol: NRG3
• Assay Reference Genome Location: Chr.10:81898475 on build GRCh38
• Cytoband: 10q23.1

Target Gene Details

• Entrez Gene ID: 10718
• Gene Name: neuregulin 3
• Gene Aliases: HRG3, pro-NRG3
• Location: Chr.10:81875298-82989979 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NRG3	NM_001010848.3			NP_001010848.2
	NM_001165972.1			NP_001159444.1
	NM_001165973.1			NP_001159445.1
	XM_005269444.4			XP_005269501.1
	XM_011539172.2			XP_011537474.1
	XM_011539173.2			XP_011537475.1
	XM_011539175.2			XP_011537477.1
	XM_017015573.1			XP_016871062.1
	XM_017015574.1			XP_016871063.1
	XM_017015575.1			XP_016871064.1
	XM_017015576.1			XP_016871065.1
	XM_017015577.1			XP_016871066.1
	XM_017015578.1			XP_016871067.1
	XM_017015579.1			XP_016871068.1
	XM_017015580.1			XP_016871069.1
	XM_017015581.1			XP_016871070.1
	XM_017015584.1			XP_016871073.1
	AK122886.1
	AK296563.1
	BC136811.1
	DQ001411.1			AAY17216.1
	DQ338459.1			ABC69293.1
	DQ857894.1
	HM068873.1
	HM068874.1
	HM068875.1
	HM068876.1
	HM068877.1
	HM068878.1
	HM068879.1
	HM068880.1
	HM068881.1
	HM068882.1
	HM068883.1
	HM068884.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv551669	Chr.10:81374678 - 82080786 on Build GRCh38	Gain	NRG3
esv3891873	Chr.10:81025608 - 82340753 on Build GRCh38	Gain	NRG3-AS1 NRG3
nsv831925	Chr.10:81771475 - 81938851 on Build GRCh38	Gain	NRG3
nsv551670	Chr.10:81545860 - 81972366 on Build GRCh38	Loss	NRG3

More Information

Additional Information:

For this assay, SNP(s) [rs79643717] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

growth factor

Gene Ontology Categories:

Process(es)

regulation of cell growth
activation of transmembrane receptor protein tyrosine kinase activity
pattern specification process
chemorepulsion involved in interneuron migration from the subpallium to the cortex
intracellular signal transduction
animal organ development
mammary placode formation
negative regulation of neuron migration

Function(s)

receptor binding
growth factor activity
transmembrane receptor protein tyrosine kinase activator activity
receptor tyrosine kinase binding
chemorepellent activity