Hs04084045_cn

• Gene Symbol: PRODH
• Assay Reference Genome Location: Chr.22:18926820 on build GRCh38
• Cytoband: 22q11.21

Target Gene Details

• Entrez Gene ID: 5625
• Gene Name: proline dehydrogenase 1
• Gene Aliases: HSPOX2, PIG6, POX, PRODH1, PRODH2, TP53I6
• Location: Chr.22:18912774-18936553 on Build GRCh38
• Assay Gene Location: Within Intron 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PRODH	NM_001195226.1			NP_001182155.1
	NM_016335.4			NP_057419.4
	BC118597.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv588196	Chr.22:18913491 - 18953944 on Build GRCh38	Gain	PRODH
esv32687	Chr.22:18158909 - 19022965 on Build GRCh38	Gain+Loss	PI4KAP1 PRODH FAM230A RIMBP3 LOC729461 GGT3P DGCR10 LOC100996432 LOC100996415 LOC102725072 LOC642643 DGCR9 TMEM191B DGCR5 LOC100996401 DGCR6 USP18
nsv588203	Chr.22:18925165 - 19020595 on Build GRCh38	Gain+Loss	PRODH DGCR9 DGCR5
nsv953020	Chr.22:18899988 - 18938787 on Build GRCh38	Deletion	PRODH DGCR6
dgv4473n100	Chr.22:18888903 - 19047585 on Build GRCh38	Gain+Loss	LOC100996432 DGCR11 PRODH DGCR10 DGCR9 DGCR2 DGCR5 DGCR6
esv3584483	Chr.22:18782908 - 19018612 on Build GRCh38	Gain	LOC100996432 LOC102725072 PRODH GGT3P DGCR9 DGCR5 DGCR6
esv2751935	Chr.22:18149609 - 19042823 on Build GRCh38	Loss	PI4KAP1 PRODH FAM230A RIMBP3 LOC729461 GGT3P DGCR10 LOC100996432 LOC100996415 LOC102725072 LOC642643 DGCR9 DGCR2 TMEM191B DGCR5 LOC100996401 DGCR6 USP18
dgv543n27	Chr.22:18890274 - 19046019 on Build GRCh38	Gain	LOC100996432 PRODH DGCR10 DGCR9 DGCR2 DGCR5 DGCR6
nsv588155	Chr.22:18795358 - 19020595 on Build GRCh38	Gain	LOC100996432 LOC102725072 PRODH DGCR9 DGCR5 DGCR6
nsv1063432	Chr.22:18902533 - 18929331 on Build GRCh38	Loss	PRODH DGCR6
esv3893431	Chr.22:18874235 - 19031473 on Build GRCh38	Gain+Loss	LOC100996432 PRODH DGCR10 DGCR9 DGCR5 DGCR6
nsv516997	Chr.22:18143870 - 19039100 on Build GRCh38	Gain+Loss	PI4KAP1 PRODH FAM230A RIMBP3 LOC729461 GGT3P DGCR10 LOC100996432 LOC100996415 LOC102725072 LOC642643 DGCR9 DGCR2 TMEM191B DGCR5 LOC100996401 DGCR6 USP18
dgv1283e212	Chr.22:18166100 - 19017223 on Build GRCh38	Gain	PI4KAP1 PRODH FAM230A RIMBP3 LOC729461 GGT3P LOC100996432 LOC100996415 LOC102725072 LOC642643 TMEM191B DGCR5 LOC100996401 DGCR6 USP18
dgv4476n100	Chr.22:18899376 - 19019471 on Build GRCh38	Gain	PRODH DGCR9 DGCR5 DGCR6
dgv99e203	Chr.22:18173093 - 19019471 on Build GRCh38	Gain+Loss	PI4KAP1 PRODH FAM230A RIMBP3 LOC729461 GGT3P LOC100996432 LOC100996415 LOC102725072 LOC642643 DGCR9 TMEM191B DGCR5 LOC100996401 DGCR6 USP18
nsv442503	Chr.22:18822597 - 19018611 on Build GRCh38	Gain	LOC100996432 LOC102725072 PRODH DGCR9 DGCR5 DGCR6
esv2758824	Chr.22:18069029 - 19074200 on Build GRCh38	Gain+Loss	PI4KAP1 PRODH FAM230A RIMBP3 LOC729461 GGT3P DGCR10 LOC100996432 LOC100996415 LOC102725072 DGCR11 LOC642643 PEX26 DGCR9 DGCR2 TMEM191B TUBA8 DGCR5 LOC100996401 DGCR6 USP18
esv3893432	Chr.22:18750783 - 19029150 on Build GRCh38	Gain	LOC100996432 LOC102725072 PRODH GGT3P DGCR10 LOC642643 DGCR9 DGCR5 DGCR6
dgv4466n100	Chr.22:18166204 - 19019471 on Build GRCh38	Gain+Loss	PI4KAP1 PRODH FAM230A RIMBP3 LOC729461 GGT3P LOC100996432 LOC100996415 LOC102725072 LOC642643 DGCR9 TMEM191B DGCR5 LOC100996401 DGCR6 USP18
dgv173e55	Chr.22:18157533 - 19070277 on Build GRCh38	Gain	PI4KAP1 PRODH FAM230A RIMBP3 LOC729461 GGT3P DGCR10 LOC100996432 LOC100996415 LOC102725072 DGCR11 LOC642643 DGCR9 DGCR2 TMEM191B DGCR5 LOC100996401 DGCR6 USP18
dgv42e213	Chr.22:18888915 - 19019471 on Build GRCh38	Gain	LOC100996432 PRODH DGCR9 DGCR5 DGCR6
dgv169n111	Chr.22:18745406 - 19019471 on Build GRCh38	Duplication	LOC100996432 LOC102725072 PRODH GGT3P LOC642643 DGCR9 DGCR5 DGCR6
dgv7975n54	Chr.22:18901977 - 19029150 on Build GRCh38	Loss	PRODH DGCR10 DGCR9 DGCR5 DGCR6
dgv4468n100	Chr.22:18760915 - 19019471 on Build GRCh38	Gain+Loss	LOC100996432 LOC102725072 PRODH GGT3P DGCR9 DGCR5 DGCR6
esv3647249	Chr.22:18924644 - 19011486 on Build GRCh38	Loss	PRODH DGCR5
nsv588201	Chr.22:18922407 - 18959084 on Build GRCh38	Loss	PRODH
dgv174e55	Chr.22:18903433 - 19050022 on Build GRCh38	Gain	DGCR11 PRODH DGCR10 DGCR9 DGCR2 DGCR5 DGCR6
esv3584485	Chr.22:18806434 - 18964032 on Build GRCh38	Gain	LOC100996432 LOC102725072 PRODH DGCR6
nsv1067175	Chr.22:18822569 - 19046938 on Build GRCh38	Loss	LOC100996432 LOC102725072 DGCR11 PRODH DGCR10 DGCR9 DGCR2 DGCR5 DGCR6
nsv979632	Chr.22:18908034 - 18929580 on Build GRCh38	Duplication	PRODH DGCR6
nsv1160726	Chr.22:18899868 - 19019471 on Build GRCh38	Duplication	PRODH DGCR9 DGCR5 DGCR6
dgv7976n54	Chr.22:18903102 - 18988074 on Build GRCh38	Gain	PRODH DGCR5 DGCR6
esv22247	Chr.22:18174171 - 18937942 on Build GRCh38	Gain+Loss	PI4KAP1 PRODH FAM230A RIMBP3 LOC729461 GGT3P LOC100996432 LOC100996415 LOC102725072 LOC642643 TMEM191B LOC100996401 DGCR6 USP18
esv3575418	Chr.22:18161776 - 19963846 on Build GRCh38	Gain	PRODH FAM230A RIMBP3 GNB1L LINC00895 C22orf39 TBX1 LOC100996432 LOC100996415 DGCR11 UFD1L HIRA SEPT5 C22orf29 CDC45 DGCR2 COMT DGCR6 USP18 SEPT5-GP1BB GP1BB PI4KAP1 GSC2 LOC729461 CLTCL1 GGT3P DGCR10 LINC01311 TSSK2 LOC102725072 TXNRD2 CLDN5 SLC25A1 MRPL40 LOC642643 DGCR9 TMEM191B DGCR5 LOC100996401 MIR4761 DGCR14

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

oxidase

Gene Ontology Categories:

Process(es)

proline metabolic process
proline catabolic process
intrinsic apoptotic signaling pathway in response to oxidative stress
proline catabolic process to glutamate
positive regulation of cell death
4-hydroxyproline catabolic process
oxidation-reduction process

Function(s)

proline dehydrogenase activity
FAD binding