Hs04073755_cn

• Gene Symbol: ITGB2
• Assay Reference Genome Location: Chr.21:44922836 on build GRCh38
• Cytoband: 21q22.3

Target Gene Details

• Entrez Gene ID: 3689
• Gene Name: integrin subunit beta 2
• Gene Aliases: CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7
• Location: Chr.21:44885949-44928873 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ITGB2	NM_001127491.2			NP_001120963.2
	AK095992.1
	AU279404.1
	DA200537.1

Target Gene Details

• Entrez Gene ID: 100505746
• Gene Name: ITGB2 antisense RNA 1
• Gene Aliases: -
• Location: Chr.21:44921035-44929680 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ITGB2-AS1	NR_038311.1
	NR_038312.1
	NR_038313.1
	NR_038314.1
	NR_038315.1
	NR_038316.1
	DA378472.1
	DA942354.1
	DA944688.1
	DA948979.1
	DB115909.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3575398	Chr.21:44921339 - 44924818 on Build GRCh38	Gain	ITGB2-AS1 ITGB2
esv3647138	Chr.21:44916487 - 44942284 on Build GRCh38	Loss	FAM207A LINC01547 ITGB2-AS1 ITGB2
nsv834110	Chr.21:44896268 - 45085236 on Build GRCh38	Loss	LINC00163 ADARB1 SSR4P1 FAM207A LINC01547 PICSAR LOC105372836 ITGB2-AS1 ITGB2

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

integrin

Gene Ontology Categories:

Process(es)

leukocyte migration involved in inflammatory response
phagocytosis
apoptotic process
inflammatory response
cell adhesion
leukocyte cell-cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
cell-cell signaling
aging
regulation of cell shape
natural killer cell activation
extracellular matrix organization
neutrophil chemotaxis
receptor internalization
heterotypic cell-cell adhesion
toll-like receptor 4 signaling pathway
endodermal cell differentiation
receptor clustering
endothelial cell migration
cellular extravasation
positive regulation of nitric oxide biosynthetic process
positive regulation of angiogenesis
regulation of peptidyl-tyrosine phosphorylation
regulation of immune response
leukocyte migration
positive regulation of NF-kappaB transcription factor activity
cellular response to low-density lipoprotein particle stimulus

Function(s)

glycoprotein binding
protein binding
protein kinase binding
ICAM-3 receptor activity
protein complex binding
metal ion binding
protein heterodimerization activity
cell adhesion molecule binding