Hs04031473_cn

• Gene Symbol: TCF3
• Assay Reference Genome Location: Chr.19:1615094 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 6929
• Gene Name: transcription factor 3
• Gene Aliases: AGM8, E2A, E47, ITF1, TCF-3, VDIR, bHLHb21
• Location: Chr.19:1609290-1652590 on Build GRCh38
• Assay Gene Location: Within Intron 17

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TCF3	NM_001136139.2			NP_001129611.1
	NM_003200.3			NP_003191.1
	XM_006722852.3			XP_006722915.1
	XM_006722853.3			XP_006722916.1
	XM_006722855.3			XP_006722918.1
	XM_006722856.3			XP_006722919.1
	XM_006722857.3			XP_006722920.1
	XM_006722858.3			XP_006722921.1
	XM_011528215.2			XP_011526517.1
	XM_011528216.2			XP_011526518.1
	XM_011528217.2			XP_011526519.1
	XM_011528219.2			XP_011526521.1
	XM_011528220.2			XP_011526522.1
	XM_011528221.2			XP_011526523.1
	XM_011528223.2			XP_011526525.1
	XM_011528225.2			XP_011526527.1
	XM_011528226.2			XP_011526528.1
	XM_011528227.2			XP_011526529.1
	XM_017027177.1			XP_016882666.1
	XM_017027178.1			XP_016882667.1
	XM_017027179.1			XP_016882668.1
	XM_017027180.1			XP_016882669.1
	XM_017027181.1			XP_016882670.1
	XM_017027182.1			XP_016882671.1
	XM_017027183.1			XP_016882672.1
	XM_017027184.1			XP_016882673.1
	AW028755.1
	BC011665.2			AAH11665.1
	BC110580.1			AAI10581.1
	KF303591.1
	M24404.1			AAA56829.1
	M24405.1			AAA56830.1
	M31523.1			AAA61146.1
	M65214.1			AAC41693.1
	X52078.1			CAA36297.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv32942	Chr.19:1320268 - 1999205 on Build GRCh38	Gain+Loss	ATP8B3 RPS15 ADAT3 MUM1 MBD3 DAZAP1 CSNK1G2 KLF16 PLK5 ADAMTSL5 ABHD17A PCSK4 MEX3D REXO1 ONECUT3 TCF3 BTBD2 GAMT C19orf25 NDUFS7 APC2 MIR1909 UQCR11 LOC100288123 REEP6 CSNK1G2-AS1 SCAMP4
nsv953942	Chr.19:1371602 - 2057401 on Build GRCh38	Deletion	ATP8B3 RPS15 ADAT3 MUM1 MBD3 DAZAP1 CSNK1G2 KLF16 PLK5 ADAMTSL5 ABHD17A PCSK4 MEX3D REXO1 ONECUT3 TCF3 BTBD2 GAMT C19orf25 NDUFS7 APC2 MKNK2 MIR1909 UQCR11 LOC100288123 REEP6 CSNK1G2-AS1 SCAMP4

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

basic helix-loop-helix transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
B cell lineage commitment
transcription, DNA-templated
regulation of transcription, DNA-templated
B cell differentiation
immunoglobulin V(D)J recombination
positive regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of muscle cell differentiation

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
transcription factor binding
mitogen-activated protein kinase kinase kinase binding
enhancer binding
protein homodimerization activity
bHLH transcription factor binding
protein heterodimerization activity
repressing transcription factor binding
vitamin D response element binding
E-box binding