Hs04017722_cn

• Gene Symbol: APC2
• Assay Reference Genome Location: Chr.19:1450484 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 10297
• Gene Name: APC2, WNT signaling pathway regulator
• Gene Aliases: APCL
• Location: Chr.19:1446268-1473244 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
APC2	NM_005883.2			NP_005874.1
	XM_005259475.2			XP_005259532.1
	XM_006722607.2			XP_006722670.1
	XM_006722608.3			XP_006722671.2
	XM_006722610.3			XP_006722673.2
	AF110334.1			AAD28183.1
	AL078616.1
	BC032573.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv32942	Chr.19:1320268 - 1999205 on Build GRCh38	Gain+Loss	KLF16 CSNK1G2-AS1 GAMT MBD3 NDUFS7 DAZAP1 CSNK1G2 LOC100288123 C19orf25 MUM1 RPS15 SCAMP4 PCSK4 REXO1 BTBD2 ADAT3 MEX3D ATP8B3 REEP6 ABHD17A MIR1909 UQCR11 ADAMTSL5 APC2 ONECUT3 TCF3 PLK5
nsv578279	Chr.19:1413575 - 1530061 on Build GRCh38	Gain	RPS15 REEP6 PCSK4 ADAMTSL5 DAZAP1 C19orf25 PLK5 APC2
nsv833705	Chr.19:1380125 - 1544934 on Build GRCh38	Loss	RPS15 GAMT REEP6 PCSK4 ADAMTSL5 NDUFS7 DAZAP1 C19orf25 PLK5 APC2
esv2758743	Chr.19:951641 - 1544934 on Build GRCh38	Gain+Loss	CIRBP-AS1 C19orf24 GAMT POLR2E CIRBP LOC102725180 NDUFS7 DAZAP1 C19orf25 ATP5D MUM1 RPS15 TMEM259 ARHGAP45 ABCA7 PCSK4 CNN2 LOC105372235 REEP6 ADAMTSL5 CBARP APC2 GPX4 SBNO2 STK11 GRIN3B WDR18 ARID3A RNU6-2 EFNA2 MIDN PLK5
nsv953942	Chr.19:1371602 - 2057401 on Build GRCh38	Deletion	KLF16 CSNK1G2-AS1 GAMT MBD3 NDUFS7 DAZAP1 CSNK1G2 LOC100288123 C19orf25 MUM1 RPS15 SCAMP4 PCSK4 REXO1 BTBD2 ADAT3 MEX3D ATP8B3 REEP6 ABHD17A MIR1909 UQCR11 ADAMTSL5 APC2 ONECUT3 MKNK2 TCF3 PLK5
nsv470105	Chr.19:1444420 - 1526614 on Build GRCh38	Gain	REEP6 PCSK4 ADAMTSL5 C19orf25 PLK5 APC2

More Information

Additional Information:

For this assay, SNP(s) [rs80271587] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

cell fate specification
negative regulation of microtubule depolymerization
pattern specification process
cell proliferation
Wnt signaling pathway
cell migration
negative regulation of catenin import into nucleus
regulation of cell differentiation
positive regulation of protein catabolic process
negative regulation of canonical Wnt signaling pathway

Function(s)

protein binding
beta-catenin binding
microtubule binding
gamma-catenin binding