Hs03911822_cn

• Gene Symbol: SEMA4B
• Assay Reference Genome Location: Chr.15:90213768 on build GRCh38
• Cytoband: 15q26.1

Target Gene Details

• Entrez Gene ID: 10509
• Gene Name: semaphorin 4B
• Gene Aliases: SEMAC, SemC
• Location: Chr.15:90184920-90229660 on Build GRCh38
• Assay Gene Location: Within Intron 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SEMA4B	NM_001324029.1			NP_001310958.1
	NM_001324030.1			NP_001310959.1
	NM_001324031.1			NP_001310960.1
	NM_001324032.1			NP_001310961.1
	NM_001324033.1			NP_001310962.1
	NM_001324034.1			NP_001310963.1
	NM_020210.3			NP_064595.2
	NM_198925.2			NP_945119.1
	AB051532.1
	AK026108.1
	AK289991.1
	AY358392.1			AAQ88758.1
	AY445887.1			AAR15707.1
	BC110853.1			AAI10854.1
	BC126438.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv833087	Chr.15:90208675 - 90425725 on Build GRCh38	Loss	SEMA4B LOC400446 NGRN CIB1 GDPGP1 GABARAPL3 TTLL13P ZNF774 IQGAP1
esv3637214	Chr.15:90184741 - 90235676 on Build GRCh38	Gain	SEMA4B CIB1 GDPGP1
nsv1052652	Chr.15:90101186 - 90298961 on Build GRCh38	Gain	SEMA4B LOC400446 NGRN CIB1 GDPGP1 IDH2 TTLL13P
dgv112e55	Chr.15:90079272 - 90249274 on Build GRCh38	Gain	SEMA4B CIB1 GDPGP1 ZNF710 IDH2
esv2760054	Chr.15:90022724 - 90266401 on Build GRCh38	Gain	SEMA4B NGRN CIB1 GDPGP1 ZNF710 IDH2 TTLL13P
nsv817707	Chr.15:90104624 - 90241698 on Build GRCh38	Gain	SEMA4B CIB1 GDPGP1
nsv442384	Chr.15:90089378 - 90235161 on Build GRCh38	Gain	SEMA4B CIB1 GDPGP1 IDH2

More Information

Additional Information:

For this assay, SNP(s) [rs150400707,rs76356360] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

membrane-bound signaling molecule, intercellular signal molecule

Gene Ontology Categories:

Process(es)

neural crest cell migration
positive regulation of cell migration
negative regulation of axon extension involved in axon guidance
negative chemotaxis
semaphorin-plexin signaling pathway

Function(s)

semaphorin receptor binding
neuropilin binding
chemorepellent activity