Hs03802524_cn

• Gene Symbol: NOX4
• Assay Reference Genome Location: Chr.11:89440188 on build GRCh38
• Cytoband: 11q14.3

Target Gene Details

• Entrez Gene ID: 50507
• Gene Name: NADPH oxidase 4
• Gene Aliases: KOX, KOX-1, RENOX
• Location: Chr.11:89324353-89589611 on Build GRCh38
• Assay Gene Location: Within Intron 13

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NOX4	NM_001143836.2			NP_001137308.1
	NM_001143837.1			NP_001137309.1
	NM_001291926.1			NP_001278855.1
	NM_001291927.1			NP_001278856.1
	NM_001291929.1			NP_001278858.1
	NM_001300995.1			NP_001287924.1
	NM_016931.4			NP_058627.1
	XM_006718849.3			XP_006718912.1
	XM_011542857.2			XP_011541159.1
	XM_017017841.1			XP_016873330.1
	XM_017017843.1			XP_016873332.1
	XM_017017844.1			XP_016873333.1
	XM_017017845.1			XP_016873334.1
	AB041035.1			BAA95695.1
	AF254621.1			AAF68973.1
	AF261943.1			AAF87572.1
	AJ704725.1			CAG28807.1
	AJ704726.1			CAG28808.1
	AJ704727.1			CAG28809.1
	AJ704728.1			CAG28810.1
	AJ704729.1			CAG28811.1
	AK057189.1
	AK291830.1
	AK298323.1
	AK298328.1
	AK298357.1
	AK298376.1
	AK311381.1
	AK311389.1
	AY288918.1			AAP41109.1
	BC040105.1			AAH40105.1
	BP376400.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv468781	Chr.11:89179523 - 89538618 on Build GRCh38	Gain	TYR NOX4
esv32702	Chr.11:88941663 - 89732700 on Build GRCh38	Gain+Loss	GRM5 TYR FOLH1B TRIM77 NOX4
nsv1037955	Chr.11:89417255 - 89459141 on Build GRCh38	Loss	NOX4
nsv469976	Chr.11:89145035 - 89542998 on Build GRCh38	Gain	TYR NOX4

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

oxidase

Gene Ontology Categories:

Process(es)

response to reactive oxygen species
cell morphogenesis
response to hypoxia
superoxide metabolic process
inflammatory response
cell aging
negative regulation of cell proliferation
gene expression
positive regulation of smooth muscle cell migration
superoxide anion generation
positive regulation of apoptotic process
positive regulation of MAP kinase activity
bone resorption
homocysteine metabolic process
positive regulation of stress fiber assembly
positive regulation of protein kinase B signaling
cardiac muscle cell differentiation
oxidation-reduction process
positive regulation of ERK1 and ERK2 cascade
cellular response to cAMP
cellular response to glucose stimulus
cellular response to gamma radiation
cellular response to transforming growth factor beta stimulus
reactive oxygen species metabolic process
positive regulation of reactive oxygen species metabolic process
positive regulation of DNA biosynthetic process

Function(s)

nucleotide binding
protein binding
electron carrier activity
NAD(P)H oxidase activity
superoxide-generating NADPH oxidase activity
oxygen sensor activity
heme binding
flavin adenine dinucleotide binding
modified amino acid binding