Hs02820140_cn

• Gene Symbol: ADORA2A
• Assay Reference Genome Location: Chr.22:24441964 on build GRCh38
• Cytoband: 22q11.23

Target Gene Details

• Entrez Gene ID: 135
• Gene Name: adenosine A2a receptor
• Gene Aliases: A2aR, ADORA2, RDC8
• Location: Chr.22:24423597-24442360 on Build GRCh38
• Assay Gene Location: Within Exon 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ADORA2A	NM_000675.5	3	2173	NP_000666.2
	NM_001278497.1	4	2344	NP_001265426.1
	NM_001278498.1	3	2238	NP_001265427.1
	NM_001278499.1	3	2153	NP_001265428.1
	NM_001278500.1	3	2020	NP_001265429.1
	NR_103543.1	2	1567
	NR_103544.1	2	1547
	AK123058.1	4	2083
	BC013780.1	3	2100	AAH13780.1
	CA307692.1	1	411
	HY249059.1	1	228
	M97370.1	2	1975	AAA58356.1

Target Gene Details

• Entrez Gene ID: 646023
• Gene Name: ADORA2A antisense RNA 1
• Gene Aliases: C22orf45
• Location: Chr.22:24429206-24495074 on Build GRCh38
• Assay Gene Location: Overlaps Intron 6 - Exon 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ADORA2A-AS1	NR_028483.2
	NR_028484.2
	DB449907.2

Target Gene Details

• Entrez Gene ID: 101730217
• Gene Name: SPECC1L-ADORA2A readthrough (NMD candidate)
• Gene Aliases: -
• Location: Chr.22:24270817-24442360 on Build GRCh38
• Assay Gene Location: Within Exon 20

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SPECC1L-ADORA2A	NR_103546.1	20	5893
	AB209022.1	20	5811	BAD92259.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2724068	Chr.22:24288741 - 24669870 on Build GRCh38	Deletion	SPECC1L-ADORA2A BCRP3 GUCD1 SNRPD3 SPECC1L ADORA2A GGT1 POM121L10P ADORA2A-AS1 LRRC75B UPB1
dgv8039n54	Chr.22:23323169 - 24601506 on Build GRCh38	Gain	SPECC1L-ADORA2A SUSD2 VPREB3 IGLL1 DDT SMARCB1 DRICH1 ZNF70 PCAT14 MIF-AS1 ADORA2A-AS1 GUCD1 GSTT2B C22orf15 GGT1 LOC107985555 UPB1 MMP11 ZDHHC8P1 LOC107985559 SNRPD3 CABIN1 ADORA2A LOC100652871 DERL3 MIF GSTT2 LRRC75B GGT5 CHCHD10 RGL4 LOC101929374 DDTL LOC388882 CES5AP1 SPECC1L GSTTP1 GUSBP11 POM121L9P SLC2A11
nsv1057819	Chr.22:24290518 - 24624081 on Build GRCh38	Gain	SPECC1L-ADORA2A GUCD1 SNRPD3 SPECC1L ADORA2A GGT1 ADORA2A-AS1 LRRC75B UPB1
nsv526567	Chr.22:23348138 - 24600663 on Build GRCh38	Gain	SPECC1L-ADORA2A SUSD2 VPREB3 IGLL1 DDT SMARCB1 DRICH1 ZNF70 PCAT14 MIF-AS1 ADORA2A-AS1 GUCD1 GSTT2B C22orf15 GGT1 LOC107985555 UPB1 MMP11 ZDHHC8P1 LOC107985559 SNRPD3 CABIN1 ADORA2A LOC100652871 DERL3 MIF GSTT2 LRRC75B GGT5 CHCHD10 RGL4 LOC101929374 DDTL LOC388882 CES5AP1 SPECC1L GSTTP1 GUSBP11 POM121L9P SLC2A11
esv2724041	Chr.22:23315914 - 24669376 on Build GRCh38	Deletion	SPECC1L-ADORA2A SUSD2 VPREB3 IGLL1 DDT SMARCB1 DRICH1 ZNF70 PCAT14 MIF-AS1 ADORA2A-AS1 BCRP3 GUCD1 GSTT2B C22orf15 GGT1 LOC107985555 UPB1 MMP11 ZDHHC8P1 LOC107985559 SNRPD3 CABIN1 ADORA2A LOC100652871 POM121L10P DERL3 MIF GSTT2 LRRC75B GGT5 CHCHD10 RGL4 LOC101929374 DDTL LOC388882 CES5AP1 SPECC1L GSTTP1 GUSBP11 POM121L9P SLC2A11 BCR
nsv1055830	Chr.22:24005071 - 24643213 on Build GRCh38	Gain	SPECC1L-ADORA2A SUSD2 SNRPD3 CABIN1 ADORA2A ADORA2A-AS1 LRRC75B GGT5 BCRP3 GUCD1 SPECC1L GSTTP1 GGT1 POM121L9P UPB1
esv3893463	Chr.22:24009046 - 24601506 on Build GRCh38	Gain	SPECC1L-ADORA2A SUSD2 SNRPD3 CABIN1 ADORA2A ADORA2A-AS1 LRRC75B GGT5 GUCD1 SPECC1L GGT1 POM121L9P UPB1
dgv4528n100	Chr.22:23322244 - 24682765 on Build GRCh38	Gain	SPECC1L-ADORA2A SUSD2 VPREB3 IGLL1 DDT SMARCB1 DRICH1 ZNF70 PCAT14 MIF-AS1 ADORA2A-AS1 BCRP3 GUCD1 GSTT2B C22orf15 GGT1 LOC107985555 UPB1 MMP11 ZDHHC8P1 LOC107985559 SNRPD3 CABIN1 ADORA2A LOC100652871 POM121L10P DERL3 MIF GSTT2 LRRC75B GGT5 CHCHD10 RGL4 LOC101929374 DDTL LOC388882 CES5AP1 SPECC1L GSTTP1 GUSBP11 POM121L9P SLC2A11
nsv588744	Chr.22:24285587 - 24617379 on Build GRCh38	Gain	SPECC1L-ADORA2A GUCD1 SNRPD3 SPECC1L ADORA2A GGT1 ADORA2A-AS1 LRRC75B UPB1
nsv9884	Chr.22:24415625 - 24662249 on Build GRCh38	Gain+Loss	SPECC1L-ADORA2A BCRP3 GUCD1 SNRPD3 SPECC1L ADORA2A GGT1 POM121L10P ADORA2A-AS1 LRRC75B UPB1
esv3575443	Chr.22:23348201 - 24670505 on Build GRCh38	Gain	SPECC1L-ADORA2A SUSD2 VPREB3 IGLL1 DDT SMARCB1 DRICH1 ZNF70 PCAT14 MIF-AS1 ADORA2A-AS1 BCRP3 GUCD1 GSTT2B C22orf15 GGT1 LOC107985555 UPB1 MMP11 ZDHHC8P1 LOC107985559 SNRPD3 CABIN1 ADORA2A LOC100652871 POM121L10P DERL3 MIF GSTT2 LRRC75B GGT5 CHCHD10 RGL4 LOC101929374 DDTL LOC388882 CES5AP1 SPECC1L GSTTP1 GUSBP11 POM121L9P SLC2A11
nsv834160	Chr.22:24329972 - 24507687 on Build GRCh38	Gain	SPECC1L-ADORA2A SPECC1L ADORA2A ADORA2A-AS1 UPB1

More Information

• Set Membership: Intragenic, Exonic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

G-protein coupled receptor

Gene Ontology Categories:

Process(es)

adenosine receptor signaling pathway
cAMP biosynthetic process
phagocytosis
apoptotic process
inflammatory response
cellular defense response
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
cell-cell signaling
central nervous system development
blood coagulation
sensory perception
blood circulation
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
cellular protein metabolic process

Function(s)

G-protein coupled adenosine receptor activity
protein binding
enzyme binding
identical protein binding