Hs02766783_cn

• Gene Symbol: RAF1
• Assay Reference Genome Location: Chr.3:12587566 on build GRCh38
• Cytoband: 3p25.2

Target Gene Details

• Entrez Gene ID: 5894
• Gene Name: Raf-1 proto-oncogene, serine/threonine kinase
• Gene Aliases: CMD1NN, CRAF, NS5, Raf-1, c-Raf
• Location: Chr.3:12583601-12664201 on Build GRCh38
• Assay Gene Location: Overlaps Intron 16 - Exon 16

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
RAF1	NM_002880.3			NP_002871.1
	XM_005265355.2			XP_005265412.1
	XM_005265357.2			XP_005265414.1
	XM_005265358.4			XP_005265415.1
	XM_005265359.4			XP_005265416.1
	XM_011533974.2			XP_011532276.1
	XM_011533975.2			XP_011532277.1
	XM_017006966.1			XP_016862455.1
	AK226028.1
	AK303561.1
	AK303920.1
	AK312248.1
	BC018119.2			AAH18119.1
	KU178297.1
	KU178298.1
	KU178299.1
	X03484.1			CAA27204.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3575548	Chr.3:12521381 - 12631860 on Build GRCh38	Gain	MKRN2 RAF1 TSEN2 MKRN2OS
nsv1000995	Chr.3:12308425 - 12594756 on Build GRCh38	Gain	MKRN2 RAF1 PPARG TSEN2 MKRN2OS
dgv597n27	Chr.3:12582571 - 12776123 on Build GRCh38	Gain	MKRN2 RAF1 TMEM40
nsv1147269	Chr.3:11914420 - 12871937 on Build GRCh38	Deletion	TIMP4 RPL32 SNORA7A MKRN2 SYN2 RAF1 TMEM40 PPARG TSEN2 CAND2 MKRN2OS
nsv1112379	Chr.3:11914395 - 12871920 on Build GRCh38	Deletion	TIMP4 RPL32 SNORA7A MKRN2 SYN2 RAF1 TMEM40 PPARG TSEN2 CAND2 MKRN2OS
esv2751977	Chr.3:12452779 - 12887049 on Build GRCh38	Gain	RPL32 SNORA7A MKRN2 RAF1 TMEM40 PPARG TSEN2 CAND2 MKRN2OS LOC105376955
dgv850e199	Chr.3:11914188 - 12872013 on Build GRCh38	Deletion	TIMP4 RPL32 SNORA7A MKRN2 SYN2 RAF1 TMEM40 PPARG TSEN2 CAND2 MKRN2OS
dgv763e201	Chr.3:11909121 - 12871926 on Build GRCh38	Deletion	TIMP4 RPL32 SNORA7A MKRN2 SYN2 RAF1 TMEM40 PPARG TSEN2 CAND2 MKRN2OS

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

MAPK cascade
activation of MAPKK activity
response to hypoxia
stimulatory C-type lectin receptor signaling pathway
protein phosphorylation
apoptotic process
signal transduction
activation of adenylate cyclase activity
heart development
cell proliferation
negative regulation of cell proliferation
cell differentiation
platelet activation
thyroid gland development
negative regulation of protein complex assembly
positive regulation of peptidyl-serine phosphorylation
ion transmembrane transport
somatic stem cell population maintenance
regulation of Rho protein signal transduction
insulin secretion involved in cellular response to glucose stimulus
response to muscle stretch
wound healing
regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
intermediate filament cytoskeleton organization
regulation of cell differentiation
positive regulation of transcription from RNA polymerase II promoter
neurotrophin TRK receptor signaling pathway
thymus development
face development
death-inducing signaling complex assembly
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of cell motility

Function(s)

protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
kinase activity
small GTPase binding
mitogen-activated protein kinase kinase binding
identical protein binding
metal ion binding
protein heterodimerization activity