Hs02723124_cn

• Gene Symbol: PTPN5
• Assay Reference Genome Location: Chr.11:18728935 on build GRCh38
• Cytoband: 11p15.1

Target Gene Details

• Entrez Gene ID: 84867
• Gene Name: protein tyrosine phosphatase, non-receptor type 5
• Gene Aliases: PTPSTEP, STEP, STEP61
• Location: Chr.11:18727928-18792721 on Build GRCh38
• Assay Gene Location: Within Exon 16

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PTPN5	NM_001039970.1	15	2032	NP_001035059.1
	NM_001278236.1	15	2866	NP_001265165.1
	NM_001278238.1	14	1995	NP_001265167.1
	NM_001278239.1	14	1899	NP_001265168.1
	NM_006906.1	15	2128	NP_008837.1
	NM_032781.3	15	2083	NP_116170.3
	XM_011520411.2	15	2114	XP_011518713.1
	XM_017018434.1	14	1906	XP_016873923.1
	XM_017018435.1	14	1876	XP_016873924.1
	XM_017018436.1	13	1812	XP_016873925.1
	XM_017018437.1	14	1830	XP_016873926.1
	XM_017018438.1	12	1591	XP_016873927.1
	XM_017018439.1	13	1717	XP_016873928.1
	XM_017018440.1	14	1953	XP_016873929.1
	AK027333.1	1	69
	AK055450.1	3	1294
	AK090923.1	15	1992	BAC03548.1
	AK127312.1	15	2866
	AK294374.1	14	1735
	AK294673.1	14	1696
	AK295604.1	14	1856
	AK316270.1
	AL832541.1	15	2127	CAD38632.2
	BC039897.1	14	1791	AAH39897.1
	BC046435.1	5	607	AAH46435.1
	BC064807.1	15	1892	AAH64807.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1047371	Chr.11:18709926 - 18741490 on Build GRCh38	Gain	IGSF22 PTPN5
nsv553633	Chr.11:18290154 - 19036904 on Build GRCh38	Gain	HPS5 MRGPRX1 UEVLD LDHAL6A IGSF22 SPTY2D1-AS1 LDHA MIR3159 TMEM86A GTF2H1 SPTY2D1 TSG101 PTPN5 LDHC
nsv525192	Chr.11:18701244 - 18771813 on Build GRCh38	Loss	TMEM86A IGSF22 PTPN5
nsv525452	Chr.11:18714400 - 18780956 on Build GRCh38	Gain	IGSF22 PTPN5

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

positive regulation of protein phosphorylation
response to amphetamine
positive regulation of receptor internalization
protein dephosphorylation
positive regulation of neuron projection development
positive regulation of protein import into nucleus, translocation
peptidyl-tyrosine dephosphorylation
exploration behavior
response to immobilization stress
response to drug
negative regulation of MAP kinase activity
positive regulation of long-term synaptic potentiation
positive regulation of neuron death
response to acetylsalicylate
positive regulation of protein targeting to mitochondrion
positive regulation of response to drug

Function(s)

phosphotyrosine binding
protein tyrosine phosphatase activity
protein binding
glutamate receptor binding
mitogen-activated protein kinase binding