Hs02686031_cn

• Gene Symbol: TP53BP2
• Assay Reference Genome Location: Chr.1:223780942 on build GRCh38
• Cytoband: 1q41

Target Gene Details

• Entrez Gene ID: 7159
• Gene Name: tumor protein p53 binding protein 2
• Gene Aliases: 53BP2, ASPP2, BBP, P53BP2, PPP1R13A
• Location: Chr.1:223779893-223845981 on Build GRCh38
• Assay Gene Location: Overlaps Intron 19 - Exon 20

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TP53BP2	NM_001031685.2			NP_001026855.2
	NM_005426.2			NP_005417.1
	XM_011544268.1			XP_011542570.1
	XM_011544269.2			XP_011542571.1
	XM_017002220.1			XP_016857709.1
	AJ318888.2			CAC83012.1
	AK294432.1
	AK294654.1
	AK294964.1
	AK295378.1
	AK316016.1
	AK316103.1
	BC040247.1
	BC058918.1
	U09582.1			AAA21597.1
	U58334.1			AAC50557.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv4698	Chr.1:223770507 - 223787519 on Build GRCh38	Insertion	CAPN2 TP53BP2
esv34082	Chr.1:223663316 - 223956807 on Build GRCh38	Loss	CAPN8 GTF2IP20 CAPN2 TP53BP2
esv2759000	Chr.1:223747518 - 224175461 on Build GRCh38	Gain+Loss	GTF2IP20 CAPN2 TP53BP2 FBXO28 LOC107985330 LOC100287497
nsv832681	Chr.1:223524706 - 223814989 on Build GRCh38	Gain	CAPN8 CAPN2 TP53BP2

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protein-binding activity modulator

Gene Ontology Categories:

Process(es)

cell cycle
signal transduction
regulation of apoptotic process
negative regulation of cell cycle
intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of execution phase of apoptosis
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of neuron death
regulation of signal transduction by p53 class mediator

Function(s)

p53 binding
SH3/SH2 adaptor activity
protein binding
SH3 domain binding
identical protein binding
NF-kappaB binding