Hs02492672_cn

• Gene Symbol: LIN7B
• Assay Reference Genome Location: Chr.19:49116331 on build GRCh38
• Cytoband: 19q13.33

Target Gene Details

• Entrez Gene ID: 64130
• Gene Name: lin-7 homolog B, crumbs cell polarity complex component
• Gene Aliases: LIN-7B, MALS-2, MALS2, VELI2
• Location: Chr.19:49114339-49118460 on Build GRCh38
• Assay Gene Location: Within Exon 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
LIN7B	NM_001308419.1			NP_001295348.1
	NM_022165.2	4	341	NP_071448.1
	XM_006723323.3	3	289	XP_006723386.1
	XM_017027131.1			XP_016882620.1
	AF311862.1	4	319	AAG34117.1
	AY358744.1	4	341	AAQ89104.1
	BC027618.2	4	315	AAH27618.1
	BM069859.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv3620n100	Chr.19:49087495 - 49147785 on Build GRCh38	Gain	SNRNP70 LIN7B PPFIA3 C19orf73
nsv833859	Chr.19:48997009 - 49173266 on Build GRCh38	Loss	MIR6798 RUVBL2 SNRNP70 CGB2 CGB8 LOC101059948 CGB1 CGB7 NTF4 TRPM4 LIN7B CGB5 KCNA7 SNAR-G1 CGB3 LHB SNAR-G2 PPFIA3 HRC C19orf73
nsv9739	Chr.19:47901840 - 50143063 on Build GRCh38	Gain+Loss	KCNJ14 PRMT1 SNAR-A5 SNORD35A ATF5 SNAR-B1 C19orf68 LIN7B TBC1D17 FGF21 SNAR-A2 SCAF1 SNAR-D NTN5 ELSPBP1 RRAS PIH1D1 ZNF473 PRR12 SNORD34 AP2A1 IZUMO1 LOC101928295 PTOV1-AS1 LOC105447645 DBP BCL2L12 SNAR-C4 KDELR1 GFY IL4I1 GRWD1 MED25 LMTK3 SPHK2 HRC MIR6798 RPL13A SNRNP70 LOC101059948 FAM83E CGB7 SNAR-C2 PPP1R15A SNAR-A14 NTF4 RASIP1 MIR4750 NUCB1 PLA2G4C-AS1 CGB5 SEC1P CGB3 BSPH1 CCDC155 SNAR-C5 SNAR-A13 FUZ RPL18 SIGLEC11 ALDH16A1 CGB1 SULT2B1 SNAR-A7 CA11 SNAR-C1 SNAR-A9 FLJ26850 SNAR-A6 SNORD32A SNAR-A8 SYNGR4 CARD8-AS1 LHB ADM5 SNAR-A1 SNORD35B PTH2 SPACA4 RPS11 LOC100287477 NUP62 CGB8 TULP2 FUT1 NUCB1-AS1 TMEM143 MIR6799 MIR4324 SNAR-A10 SIGLEC16 MIR4751 MAMSTR SNAR-G2 PRRG2 SNAR-B2 PPFIA3 SNAR-A12 SLC6A16 CCDC114 SLC17A7 RUVBL2 MIR5088 AKT1S1 LOC105372430 SNAR-C3 RCN3 FCGRT PLEKHA4 TEAD2 DHDH ZNF114 TSKS SNORD33 LIG1 MIR4749 PTOV1-AS2 BCAT2 FUT2 CYTH2 GYS1 GRIN2D IRF3 SNAR-A11 CARD8 CPT1C MIR6800 PNKP SNAR-A3 CABP5 CGB2 FTL EMP3 PTOV1 MIR150 TRPM4 FLT3LG BAX CD37 HSD17B14 VRK3 KCNA7 SNAR-G1 PLA2G4C SNAR-A4 DKKL1 C19orf73 NOSIP
dgv3621n100	Chr.19:49092699 - 49163985 on Build GRCh38	Gain	SNRNP70 TRPM4 LIN7B PPFIA3 HRC C19orf73
esv2760526	Chr.19:49115521 - 49170761 on Build GRCh38	Gain	TRPM4 LIN7B PPFIA3 HRC C19orf73
nsv833857	Chr.19:48914476 - 49146320 on Build GRCh38	Loss	MIR6798 RUVBL2 SNRNP70 CGB2 CGB8 LOC101059948 CGB1 NUCB1-AS1 CGB7 FTL NTF4 BAX LIN7B GYS1 NUCB1 CGB5 KCNA7 SNAR-G1 CGB3 DHDH LHB SNAR-G2 PPFIA3 C19orf73
dgv3619n100	Chr.19:49067856 - 49147785 on Build GRCh38	Gain	SNRNP70 KCNA7 LIN7B PPFIA3 C19orf73
esv1011024	Chr.19:49114250 - 49117866 on Build GRCh38	Deletion	LIN7B

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

cell junction protein

Gene Ontology Categories:

Process(es)

exocytosis
neurotransmitter secretion
protein transport
maintenance of epithelial cell apical/basal polarity
protein localization to basolateral plasma membrane

Function(s)

protein domain specific binding
PDZ domain binding