Hs02397579_cn

• Gene Symbol: NKX3-1
• Assay Reference Genome Location: Chr.8:23681540 on build GRCh38
• Cytoband: 8p21.2

Target Gene Details

• Entrez Gene ID: 4824
• Gene Name: NK3 homeobox 1
• Gene Aliases: BAPX2, NKX3, NKX3.1, NKX3A
• Location: Chr.8:23678693-23682937 on Build GRCh38
• Assay Gene Location: Within Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NKX3-1	NM_001256339.1	3	161	NP_001243268.1
	NM_006167.3	2	434	NP_006158.2
	AF247704.1	2	434	AAG09781.1
	AF249669.1	3	264	AAG39735.1
	AF249670.1	2	249	AAG39736.1
	AF249671.1	3	189	AAG39737.1
	AF249672.1	3	171	AAG39738.1
	BC074863.2	2	418	AAH74863.1
	BC074864.2	2	418	AAH74864.1
	U80669.1	2	415	AAB38747.1
	U91540.1	2	386	AAB68662.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv831269	Chr.8:23661667 - 23849831 on Build GRCh38	Gain	NKX3-1 NKX2-6 STC1
nsv1028341	Chr.8:23550380 - 24287905 on Build GRCh38	Gain	SLC25A37 NKX3-1 NKX2-6 STC1

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

homeodomain transcription factor

Gene Ontology Categories:

Process(es)

metanephros development
somitogenesis
positive regulation of protein phosphorylation
transcription, DNA-templated
regulation of transcription, DNA-templated
activation of cysteine-type endopeptidase activity involved in apoptotic process
multicellular organism development
salivary gland development
heart development
positive regulation of cell proliferation
negative regulation of cell proliferation
male gonad development
positive regulation of gene expression
negative regulation of gene expression
positive regulation of cell death
positive regulation of phosphatidylinositol 3-kinase signaling
androgen receptor signaling pathway
activation of protein kinase activity
response to testosterone
cellular response to drug
dorsal aorta development
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein kinase B signaling
negative regulation of insulin-like growth factor receptor signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
negative regulation of mitotic cell cycle
positive regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
branching morphogenesis of an epithelial tube
negative regulation of epithelial cell proliferation
positive regulation of cell division
pharyngeal system development
branching involved in prostate gland morphogenesis
epithelial cell proliferation involved in salivary gland morphogenesis
negative regulation of epithelial cell proliferation involved in prostate gland development
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to steroid hormone stimulus
cellular response to hypoxia
mitotic cell cycle arrest
negative regulation of estrogen receptor binding
positive regulation of androgen secretion
positive regulation of response to DNA damage stimulus
positive regulation of apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway

Function(s)

transcription regulatory region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter sequence-specific
core promoter binding
transcription factor activity, sequence-specific DNA binding
androgen receptor activity
protein binding
transcription factor binding
cysteine-type endopeptidase activator activity involved in apoptotic process
estrogen receptor activity
protein kinase activator activity
estrogen receptor binding
histone deacetylase binding
sequence-specific DNA binding
protein self-association
transcription regulatory region DNA binding
MADS box domain binding