Hs02317040_cn

• Gene Symbol: DHODH
• Assay Reference Genome Location: Chr.16:72024193 on build GRCh38
• Cytoband: 16q22.2

Target Gene Details

• Entrez Gene ID: 1723
• Gene Name: dihydroorotate dehydrogenase (quinone)
• Gene Aliases: DHOdehase, POADS, URA1
• Location: Chr.16:72008744-72027659 on Build GRCh38
• Assay Gene Location: Within Exon 11

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DHODH	NM_001361.4	9	1203	NP_001352.2
	XM_005255827.3	9	1508	XP_005255884.1
	XM_005255829.3	8	1145	XP_005255886.1
	XM_017022990.1	9	1283	XP_016878479.1
	AK097300.1	4	1847
	AK292293.1	10	1359
	BC065245.1	9	1183	AAH65245.1
	M94065.1	10	1185	AAA50163.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1055854	Chr.16:71888241 - 72048987 on Build GRCh38	Loss	TXNL4B PKD1L3 IST1 DHODH
esv3582296	Chr.16:71965845 - 72027933 on Build GRCh38	Loss	PKD1L3 DHODH
esv2758654	Chr.16:71942441 - 72240448 on Build GRCh38	Gain	HPR TXNL4B PMFBP1 PKD1L3 HP DHODH DHX38
esv2714683	Chr.16:71950823 - 72151945 on Build GRCh38	Deletion	HPR TXNL4B PMFBP1 PKD1L3 HP DHODH DHX38
nsv833273	Chr.16:71937902 - 72118955 on Build GRCh38	Loss	HPR TXNL4B PMFBP1 PKD1L3 HP DHODH DHX38

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

dehydrogenase

Gene Ontology Categories:

Process(es)

'de novo' pyrimidine nucleobase biosynthetic process
female pregnancy
lactation
response to caffeine
response to drug
response to starvation
positive regulation of apoptotic process
'de novo' UMP biosynthetic process
pyrimidine nucleoside biosynthetic process
oxidation-reduction process
regulation of mitochondrial fission

Function(s)

dihydroorotate dehydrogenase activity
drug binding
FMN binding
ubiquinone binding