Hs02059423_cn

• Gene Symbol: HAVCR2
• Assay Reference Genome Location: Chr.5:157106637 on build GRCh38
• Cytoband: 5q33.3

Target Gene Details

• Entrez Gene ID: 84868
• Gene Name: hepatitis A virus cellular receptor 2
• Gene Aliases: CD366, HAVcr-2, KIM-3, TIM3, TIMD-3, TIMD3, Tim-3
• Location: Chr.5:157085832-157109237 on Build GRCh38
• Assay Gene Location: Overlaps Intron 2 - Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
HAVCR2	NM_032782.4			NP_116171.3
	AB924452.1
	AF251707.1			AAM19100.1
	AF450242.1			AAL65157.1
	AF450243.1			AAL65158.1
	AK027334.1			BAB55044.1
	AK314406.1
	AY069944.1			AAL55401.1
	BC020843.1	2	493	AAH20843.1
	BC063431.1			AAH63431.1
	BP291914.1
	JX049979.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1109742	Chr.5:157099986 - 157110561 on Build GRCh38	Deletion	HAVCR2
esv3575892	Chr.5:156975204 - 157220778 on Build GRCh38	Gain	ITK FAM71B HAVCR1 HAVCR2 MED7

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

immunoglobulin receptor superfamily

Gene Ontology Categories:

Process(es)

adaptive immune response
macrophage activation involved in immune response
natural killer cell tolerance induction
regulation of tolerance induction dependent upon immune response
negative regulation of T-helper 1 type immune response
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
inflammatory response
negative regulation of gene expression
negative regulation of myeloid dendritic cell activation
negative regulation of NF-kappaB transcription factor activity
negative regulation of interferon-alpha production
negative regulation of interferon-gamma production
negative regulation of interleukin-2 production
negative regulation of interleukin-3 production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
positive regulation of chemokine production
positive regulation of interferon-gamma production
positive regulation of interleukin-1 production
positive regulation of interleukin-4 production
negative regulation of natural killer cell activation
toll-like receptor 3 signaling pathway
toll-like receptor 7 signaling pathway
toll-like receptor 9 signaling pathway
positive regulation of T cell proliferation
negative regulation of T cell proliferation
positive regulation of macrophage activation
innate immune response
defense response to Gram-positive bacterium
maternal process involved in female pregnancy
positive regulation of ERK1 and ERK2 cascade
cellular response to lipopolysaccharide
negative regulation of granulocyte colony-stimulating factor production
negative regulation of defense response to bacterium
positive regulation of defense response to bacterium
positive regulation of NIK/NF-kappaB signaling
positive regulation of tumor necrosis factor secretion
negative regulation of immunological synapse formation
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Function(s)

protein binding
metal ion binding