Hs01705283_cn

• Gene Symbol: PTPN5
• Assay Reference Genome Location: Chr.11:18732683 on build GRCh38
• Cytoband: 11p15.1

Target Gene Details

• Entrez Gene ID: 84867
• Gene Name: protein tyrosine phosphatase, non-receptor type 5
• Gene Aliases: PTPSTEP, STEP, STEP61
• Location: Chr.11:18727928-18792721 on Build GRCh38
• Assay Gene Location: Overlaps Intron 12 - Exon 13

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PTPN5	NM_001039970.1			NP_001035059.1
	NM_001278236.1			NP_001265165.1
	NM_001278238.1			NP_001265167.1
	NM_001278239.1			NP_001265168.1
	NM_006906.1			NP_008837.1
	NM_032781.3			NP_116170.3
	XM_011520411.2			XP_011518713.1
	XM_017018434.1			XP_016873923.1
	XM_017018435.1			XP_016873924.1
	XM_017018436.1			XP_016873925.1
	XM_017018437.1			XP_016873926.1
	XM_017018438.1			XP_016873927.1
	XM_017018439.1			XP_016873928.1
	XM_017018440.1			XP_016873929.1
	XM_017018441.1			XP_016873930.1
	AK090923.1			BAC03548.1
	AK127312.1
	AK294374.1
	AK294673.1
	AK295604.1
	AK316270.1
	AL832541.1			CAD38632.2
	BC039897.1			AAH39897.1
	BC046435.1			AAH46435.1
	BC064807.1			AAH64807.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1047371	Chr.11:18709926 - 18741490 on Build GRCh38	Gain	IGSF22 PTPN5
nsv553633	Chr.11:18290154 - 19036904 on Build GRCh38	Gain	IGSF22 TMEM86A TSG101 HPS5 MIR3159 GTF2H1 LDHAL6A UEVLD LDHC PTPN5 SPTY2D1 SPTY2D1-AS1 MRGPRX1 LDHA
nsv525192	Chr.11:18701244 - 18771813 on Build GRCh38	Loss	IGSF22 TMEM86A PTPN5
nsv525452	Chr.11:18714400 - 18780956 on Build GRCh38	Gain	IGSF22 PTPN5

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

positive regulation of protein phosphorylation
response to amphetamine
positive regulation of receptor internalization
protein dephosphorylation
positive regulation of neuron projection development
positive regulation of protein import into nucleus, translocation
peptidyl-tyrosine dephosphorylation
exploration behavior
response to immobilization stress
response to drug
negative regulation of MAP kinase activity
positive regulation of long-term synaptic potentiation
positive regulation of neuron death
response to acetylsalicylate
positive regulation of protein targeting to mitochondrion
positive regulation of response to drug

Function(s)

phosphotyrosine binding
protein tyrosine phosphatase activity
protein binding
glutamate receptor binding
mitogen-activated protein kinase binding