Hs01701707_cn

• Gene Symbol: ASCL2
• Assay Reference Genome Location: Chr.11:2270518 on build GRCh38
• Cytoband: 11p15.5

Target Gene Details

• Entrez Gene ID: 430
• Gene Name: achaete-scute family bHLH transcription factor 2
• Gene Aliases: ASH2, HASH2, MASH2, bHLHa45
• Location: Chr.11:2268498-2270952 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ASCL2	NM_005170.2	1	435	NP_005161.1
	BC057801.1	1	71
	BC136561.1	1	160
	BC136567.1	1	161

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951285	Chr.11:2256071 - 2310670 on Build GRCh38	Deletion	ASCL2 C11orf21 TSPAN32
nsv553047	Chr.11:1733170 - 2418537 on Build GRCh38	Gain	MIR4686 MRPL23 LINC01219 SNORD131 IFITM10 HOTS INS-IGF2 MIR7847 CD81 TNNT3 IGF2 TSSC4 TH MIR4298 LSP1 SYT8 LINC01150 CTSD MIR675 TSPAN32 TRPM5 ASCL2 MRPL23-AS1 H19 INS IGF2-AS CD81-AS1 C11orf21 MIR483 TNNI2

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

basic helix-loop-helix transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
response to hypoxia
placenta development
transcription, DNA-templated
regulation of transcription, DNA-templated
negative regulation of Schwann cell proliferation
somatic stem cell population maintenance
regulation of neurogenesis
spongiotrophoblast differentiation
spongiotrophoblast layer development

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein dimerization activity
E-box binding