Hs00994207_cn

• Gene Symbol: HES4
• Assay Reference Genome Location: Chr.1:999369 on build GRCh38
• Cytoband: 1p36.33

Target Gene Details

• Entrez Gene ID: 57801
• Gene Name: hes family bHLH transcription factor 4
• Gene Aliases: bHLHb42
• Location: Chr.1:998962-1001052 on Build GRCh38
• Assay Gene Location: Within Exon 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
HES4	NM_001142467.1	3	633	NP_001135939.1
	NM_021170.3	4	555	NP_066993.1
	XM_005244771.4	3	1339	XP_005244828.1
	AB048791.1	4	356	BAB13510.1
	BC012351.1	4	473	AAH12351.1
	BI757407.1	3	633

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2762302	Chr.1:914637 - 1106320 on Build GRCh38	Gain	NOC2L PLEKHN1 LOC100130417 ISG15 AGRN RNF223 PERM1 SAMD11 KLHL17 LOC100288175 LOC284600 C1orf159 LOC105378948 HES4 LOC107985728
nsv482937	Chr.1:10001 - 2368561 on Build GRCh38	Loss	ATAD3A TTLL10-AS1 SCNN1D PLEKHN1 TMEM52 FAM41C TTLL10 TMEM240 CPTP LOC100132287 MIB2 MMP23A LINC01342 NADK LOC105378589 MIR6859-1 LOC105378591 CALML6 TMEM88B CDK11B MIR200B B3GALT6 LOC100129534 MORN1 LOC100133331 CFAP74 ANKRD65 TAS1R3 C1orf159 VWA1 GABRD DVL1 TNFRSF4 DDX11L1 ISG15 LOC102725121 PUSL1 MTND1P23 LOC101928626 MIR6723 OR4F16 LOC107985728 PRKCZ MIR6859-2 FNDC10 SLC35E2B MIR6808 LOC100287934 LOC107984841 LINC01128 MXRA8 ATAD3C ATAD3B GNB1 MTND2P28 SKI LOC729737 RNF223 FAM87B AURKAIP1 MMP23B KLHL17 LINC00115 LOC284600 LOC148413 OR4F5 TNFRSF18 LOC100288069 MIR6727 LOC100130417 AGRN LOC100506504 LOC105378949 MIR200A PERM1 LOC102724312 LOC100288175 FAAP20 SLC35E2 NOC2L MIR429 WASH7P ACAP3 SAMD11 LOC105378592 HES4 CDK11A MIR1302-2 CCNL2 MRPL20 FAM138A OR4F29 SDF4 LOC107985729 CPSF3L LOC105378947 LOC100134822 SSU72 UBE2J2 MIR6726 LOC105378948 FAM132A
nsv950451	Chr.1:899421 - 1094520 on Build GRCh38	Deletion	NOC2L PLEKHN1 LOC100130417 ISG15 AGRN RNF223 PERM1 SAMD11 KLHL17 LOC100288175 LOC284600 C1orf159 LOC105378948 HES4 LOC107985728
nsv428334	Chr.1:874371 - 1220569 on Build GRCh38	Gain	NOC2L TTLL10-AS1 MIR429 PLEKHN1 TNFRSF4 FAM41C TTLL10 ISG15 RNF223 SAMD11 LINC01342 KLHL17 LOC284600 HES4 LOC107985728 TNFRSF18 LOC100130417 MIR200B AGRN SDF4 MIR200A PERM1 LOC100288175 C1orf159 LOC105378948
nsv10161	Chr.1:776731 - 1777210 on Build GRCh38	Gain+Loss	ATAD3A ATAD3B TTLL10-AS1 SCNN1D PLEKHN1 FAM41C TTLL10 TMEM240 RNF223 FAM87B CPTP AURKAIP1 MIB2 MMP23A MMP23B LINC01342 NADK KLHL17 LINC00115 LOC284600 LOC148413 TNFRSF18 LOC100288069 TMEM88B MIR6727 CDK11B LOC100130417 MIR200B AGRN B3GALT6 MIR200A PERM1 ANKRD65 TAS1R3 LOC102724312 LOC100288175 C1orf159 SLC35E2 NOC2L MIR429 VWA1 DVL1 TNFRSF4 ISG15 PUSL1 ACAP3 SAMD11 HES4 LOC107985728 CDK11A CCNL2 MRPL20 FNDC10 SLC35E2B SDF4 LOC107985729 MIR6808 CPSF3L LOC100287934 SSU72 UBE2J2 MIR6726 LINC01128 MXRA8 LOC105378948 ATAD3C FAM132A
dgv5n100	Chr.1:585989 - 1114424 on Build GRCh38	Gain	NOC2L PLEKHN1 MTND2P28 FAM41C ISG15 RNF223 FAM87B MTND1P23 SAMD11 KLHL17 LOC101928626 LINC00115 MIR6723 LOC284600 OR4F16 HES4 LOC107985728 LOC100288069 LOC100130417 AGRN PERM1 LOC105378947 LOC100287934 LOC100133331 LOC107984841 LOC100288175 LINC01128 C1orf159 LOC105378948
nsv517709	Chr.1:817186 - 1275912 on Build GRCh38	Gain+Loss	NOC2L TTLL10-AS1 MIR429 PLEKHN1 TNFRSF4 FAM41C TTLL10 ISG15 RNF223 FAM87B SAMD11 LINC01342 KLHL17 LINC00115 LOC284600 HES4 LOC107985728 TNFRSF18 LOC100130417 MIR200B AGRN B3GALT6 SDF4 MIR200A PERM1 UBE2J2 LOC100288175 LINC01128 C1orf159 LOC105378948 FAM132A
nsv827252	Chr.1:998725 - 1001127 on Build GRCh38	Gain	HES4
nsv1013524	Chr.1:939510 - 1161955 on Build GRCh38	Gain	NOC2L PLEKHN1 ISG15 AGRN RNF223 PERM1 SAMD11 LINC01342 KLHL17 LOC100288175 C1orf159 LOC105378948 HES4
nsv1160644	Chr.1:939652 - 1220663 on Build GRCh38	Deletion	NOC2L TTLL10-AS1 MIR429 PLEKHN1 TNFRSF4 TTLL10 MIR200B ISG15 AGRN SDF4 RNF223 MIR200A PERM1 SAMD11 LINC01342 KLHL17 LOC100288175 C1orf159 LOC105378948 HES4 TNFRSF18
nsv544895	Chr.1:917392 - 1054900 on Build GRCh38	Loss	NOC2L PERM1 SAMD11 PLEKHN1 LOC100130417 KLHL17 ISG15 AGRN LOC284600 HES4 LOC107985728
dgv2n67	Chr.1:877618 - 1426500 on Build GRCh38	Gain	NOC2L TTLL10-AS1 MIR429 SCNN1D PLEKHN1 DVL1 TNFRSF4 TTLL10 ISG15 RNF223 CPTP AURKAIP1 PUSL1 ACAP3 SAMD11 LINC01342 KLHL17 LOC284600 LOC148413 HES4 LOC107985728 TNFRSF18 TMEM88B MIR6727 CCNL2 LOC100130417 MRPL20 MIR200B AGRN B3GALT6 SDF4 MIR200A MIR6808 PERM1 CPSF3L UBE2J2 ANKRD65 TAS1R3 MIR6726 LOC100288175 MXRA8 C1orf159 LOC105378948 FAM132A
nsv832980	Chr.1:848279 - 1007037 on Build GRCh38	Gain	NOC2L PERM1 SAMD11 PLEKHN1 LOC100130417 KLHL17 FAM41C LINC01128 LOC284600 HES4 LOC107985728

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

basic helix-loop-helix transcription factor

Gene Ontology Categories:

Process(es)

transcription, DNA-templated
regulation of transcription, DNA-templated
nervous system development
cell differentiation

Function(s)

DNA binding
transcription factor binding
protein dimerization activity