Hs00989887_cn

• Gene Symbol: HTRA3
• Assay Reference Genome Location: Chr.4:8282463 on build GRCh38
• Cytoband: 4p16.1

Target Gene Details

• Entrez Gene ID: 94031
• Gene Name: HtrA serine peptidase 3
• Gene Aliases: Prsp, Tasp
• Location: Chr.4:8269757-8307111 on Build GRCh38
• Assay Gene Location: Overlaps Intron 1 - Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
HTRA3	NM_001297559.1			NP_001284488.1
	NM_053044.4			NP_444272.1
	XM_011513596.2			XP_011511898.1
	AL547377.3
	AY040094.2			AAK71475.2
	AY280665.1			AAP42282.1
	AY280666.1			AAP42283.1
	BC034390.1			AAH34390.1
	BC035717.1			AAH35717.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv593627	Chr.4:8200484 - 8309316 on Build GRCh38	Gain	SH3TC1 HTRA3
nsv829853	Chr.4:8170338 - 8319141 on Build GRCh38	Gain+Loss	SH3TC1 HTRA3
nsv461218	Chr.4:8253057 - 8318399 on Build GRCh38	Loss	HTRA3
nsv949784	Chr.4:8163674 - 8297873 on Build GRCh38	Deletion	SH3TC1 HTRA3
nsv1002794	Chr.4:8108356 - 8489207 on Build GRCh38	Gain	TRMT44 ACOX3 SH3TC1 ABLIM2 HTRA3
esv3575676	Chr.4:8264103 - 8287326 on Build GRCh38	Gain	HTRA3
nsv1009011	Chr.4:8223942 - 8423104 on Build GRCh38	Loss	ACOX3 SH3TC1 HTRA3

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

serine protease

Gene Ontology Categories:

Process(es)

regulation of cell growth
proteolysis
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway

Function(s)

endopeptidase activity
serine-type endopeptidase activity
protein binding
insulin-like growth factor binding
serine-type peptidase activity