Hs00737150_cn

• Gene Symbol: TCF3
• Assay Reference Genome Location: Chr.19:1610460 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 6929
• Gene Name: transcription factor 3
• Gene Aliases: AGM8, E2A, E47, ITF1, TCF-3, VDIR, bHLHb21
• Location: Chr.19:1609290-1652590 on Build GRCh38
• Assay Gene Location: Within Exon 20

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TCF3	NM_001136139.2	19	2908	NP_001129611.1
	NM_003200.3	19	3281	NP_003191.1
	XM_006722852.3	20	2253	XP_006722915.1
	XM_006722853.3			XP_006722916.1
	XM_006722855.3	20	3111	XP_006722918.1
	XM_006722856.3	20	2243	XP_006722919.1
	XM_006722857.3	20	3109	XP_006722920.1
	XM_006722858.3	20	2241	XP_006722921.1
	XM_011528215.2	18	4754	XP_011526517.1
	XM_011528216.2	19	3455	XP_011526518.1
	XM_011528217.2	19	3458	XP_011526519.1
	XM_011528219.2	19	3453	XP_011526521.1
	XM_011528220.2	19	3445	XP_011526522.1
	XM_011528221.2	19	3443	XP_011526523.1
	XM_011528223.2	19	3364	XP_011526525.1
	XM_011528225.2	19	3355	XP_011526527.1
	XM_011528226.2	19	3355	XP_011526528.1
	XM_011528227.2	17	3204	XP_011526529.1
	XM_017027177.1	20	3121	XP_016882666.1
	XM_017027178.1			XP_016882667.1
	XM_017027179.1	20	3109	XP_016882668.1
	XM_017027180.1	16	3382	XP_016882669.1
	XM_017027181.1	20	3033	XP_016882670.1
	XM_017027182.1	20	3023	XP_016882671.1
	XM_017027183.1			XP_016882672.1
	AK310998.1
	BC011665.2	16	3025	AAH11665.1
	M31523.1	18	3242	AAA61146.1
	X52078.1	16	1793	CAA36297.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv32942	Chr.19:1320268 - 1999205 on Build GRCh38	Gain+Loss	ADAMTSL5 MBD3 TCF3 MUM1 MEX3D LOC100288123 CSNK1G2 SCAMP4 ATP8B3 APC2 DAZAP1 UQCR11 C19orf25 MIR1909 KLF16 ONECUT3 CSNK1G2-AS1 RPS15 REEP6 NDUFS7 GAMT BTBD2 PCSK4 ADAT3 ABHD17A REXO1 PLK5
nsv953942	Chr.19:1371602 - 2057401 on Build GRCh38	Deletion	ADAMTSL5 MBD3 TCF3 MUM1 MEX3D LOC100288123 MKNK2 CSNK1G2 SCAMP4 ATP8B3 APC2 DAZAP1 UQCR11 C19orf25 MIR1909 KLF16 ONECUT3 CSNK1G2-AS1 RPS15 REEP6 NDUFS7 GAMT BTBD2 PCSK4 ADAT3 ABHD17A REXO1 PLK5

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

basic helix-loop-helix transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
B cell lineage commitment
transcription, DNA-templated
regulation of transcription, DNA-templated
B cell differentiation
immunoglobulin V(D)J recombination
positive regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of muscle cell differentiation

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
transcription factor binding
mitogen-activated protein kinase kinase kinase binding
enhancer binding
protein homodimerization activity
bHLH transcription factor binding
protein heterodimerization activity
repressing transcription factor binding
vitamin D response element binding
E-box binding