Hs00683091_cn

• Gene Symbol: SIGIRR
• Assay Reference Genome Location: Chr.11:407865 on build GRCh38
• Cytoband: 11p15.5

Target Gene Details

• Entrez Gene ID: 59307
• Gene Name: single Ig and TIR domain containing
• Gene Aliases: IL-1R8, TIR8
• Location: Chr.11:405716-417454 on Build GRCh38
• Assay Gene Location: Overlaps Intron 6 - Exon 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SIGIRR	NM_001135053.1			NP_001128525.1
	NM_001135054.1			NP_001128526.1
	NM_021805.2			NP_068577.2
	XM_005253044.2			XP_005253101.1
	XM_005253045.1			XP_005253102.1
	XM_005253046.1			XP_005253103.1
	XM_005253048.4			XP_005253105.1
	XM_017018099.1			XP_016873588.1
	XM_017018100.1			XP_016873589.1
	AK025099.1			BAB15066.1
	AK093427.1
	AK172830.1			BAD18795.1
	AY358342.1			AAQ88708.1
	BC003591.1			AAH03591.1
	BC025953.1			AAH25953.1
	BC106007.1			AAI06008.1
	CR457338.1			CAG33619.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv527327	Chr.11:295343 - 620599 on Build GRCh38	Loss	PHRF1 MIR210HG MIR210 IFITM2 PTDSS2 LRRC56 CDHR5 PGGHG RASSF7 LOC143666 IFITM3 IRF7 LOC101059906 IFITM5 IFITM1 HRAS ANO9 SIGIRR B4GALNT4 LMNTD2 PKP3 RNH1
nsv469923	Chr.11:378188 - 1302334 on Build GRCh38	Loss	TSPAN4 TOLLIP LOC101927503 MIR210HG MIR210 CEND1 CDHR5 MUC5B CHID1 LOC143666 MIR6744 CRACR2B IRF7 LOC101059906 ANO9 SIGIRR B4GALNT4 PKP3 SCT MUC5AC CD151 RNH1 MUC2 DRD4 SNORA52 PHRF1 SLC25A22 PANO1 PTDSS2 MUC6 LRRC56 RPLP2 PNPLA2 TMEM80 PIDD1 RASSF7 HRAS TALDO1 LMNTD2 DEAF1 AP2A2 EPS8L2 POLR2L LOC171391 PDDC1
nsv552776	Chr.11:366710 - 432436 on Build GRCh38	Loss	ANO9 SIGIRR B4GALNT4 PKP3
nsv951268	Chr.11:368601 - 503700 on Build GRCh38	Deletion	ANO9 SIGIRR B4GALNT4 PTDSS2 PKP3 RNH1
nsv552770	Chr.11:356090 - 444628 on Build GRCh38	Gain	ANO9 SIGIRR B4GALNT4 PKP3
dgv1505n54	Chr.11:198510 - 470331 on Build GRCh38	Gain	MIR6743 PSMD13 ODF3 IFITM2 PTDSS2 PGGHG IFITM3 IFITM5 IFITM1 SIRT3 NLRP6 ANO9 BET1L SIGIRR B4GALNT4 PKP3 RIC8A
nsv1159790	Chr.11:340219 - 491334 on Build GRCh38	Deletion	ANO9 SIGIRR B4GALNT4 PTDSS2 PKP3
dgv182e199	Chr.11:349830 - 943372 on Build GRCh38	Deletion	TSPAN4 MIR210HG MIR210 CEND1 CDHR5 CHID1 LOC143666 CRACR2B IRF7 LOC101059906 ANO9 SIGIRR B4GALNT4 PKP3 SCT CD151 RNH1 DRD4 SNORA52 PHRF1 SLC25A22 PANO1 PTDSS2 LRRC56 RPLP2 PNPLA2 TMEM80 PIDD1 RASSF7 HRAS TALDO1 LMNTD2 DEAF1 AP2A2 EPS8L2 POLR2L LOC171391 PDDC1
nsv552822	Chr.11:403545 - 408352 on Build GRCh38	Loss	SIGIRR PKP3

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

negative regulation of cytokine-mediated signaling pathway
acute-phase response
signal transduction
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of chemokine biosynthetic process

Function(s)

protein binding