Hs00515718_cn

• Gene Symbol: APC2
• Assay Reference Genome Location: Chr.19:1453456 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 10297
• Gene Name: APC2, WNT signaling pathway regulator
• Gene Aliases: APCL
• Location: Chr.19:1446268-1473244 on Build GRCh38
• Assay Gene Location: Overlaps Intron 5 - Exon 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
APC2	NM_005883.2			NP_005874.1
	XM_005259475.2			XP_005259532.1
	XM_006722607.2			XP_006722670.1
	XM_006722608.3			XP_006722671.2
	XM_006722609.3			XP_006722672.1
	XM_006722610.3			XP_006722673.2
	AB012162.1			BAA34611.1
	AF110334.1			AAD28183.1
	AF128222.1			AAF01784.1
	AJ012652.1			CAB61207.1
	AL078616.1
	BC032573.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv32942	Chr.19:1320268 - 1999205 on Build GRCh38	Gain+Loss	REXO1 SCAMP4 CSNK1G2-AS1 MBD3 ABHD17A BTBD2 ONECUT3 ADAT3 ATP8B3 NDUFS7 RPS15 APC2 GAMT C19orf25 KLF16 DAZAP1 ADAMTSL5 MEX3D CSNK1G2 UQCR11 MIR1909 MUM1 LOC100288123 PLK5 REEP6 TCF3 PCSK4
nsv578279	Chr.19:1413575 - 1530061 on Build GRCh38	Gain	PLK5 REEP6 APC2 C19orf25 PCSK4 DAZAP1 ADAMTSL5 RPS15
nsv833705	Chr.19:1380125 - 1544934 on Build GRCh38	Loss	PLK5 REEP6 APC2 GAMT C19orf25 PCSK4 DAZAP1 NDUFS7 ADAMTSL5 RPS15
esv2758743	Chr.19:951641 - 1544934 on Build GRCh38	Gain+Loss	POLR2E MIDN EFNA2 GPX4 CIRBP-AS1 TMEM259 NDUFS7 RPS15 CBARP LOC102725180 APC2 ABCA7 GAMT C19orf25 STK11 ATP5D DAZAP1 ADAMTSL5 WDR18 CIRBP GRIN3B C19orf24 SBNO2 RNU6-2 ARHGAP45 ARID3A MUM1 CNN2 PLK5 REEP6 LOC105372235 PCSK4
nsv953942	Chr.19:1371602 - 2057401 on Build GRCh38	Deletion	REXO1 SCAMP4 CSNK1G2-AS1 MBD3 ABHD17A BTBD2 ONECUT3 ADAT3 ATP8B3 NDUFS7 RPS15 APC2 GAMT C19orf25 KLF16 DAZAP1 ADAMTSL5 MEX3D CSNK1G2 UQCR11 MKNK2 MIR1909 MUM1 LOC100288123 PLK5 REEP6 TCF3 PCSK4
nsv470105	Chr.19:1444420 - 1526614 on Build GRCh38	Gain	PLK5 REEP6 APC2 C19orf25 PCSK4 ADAMTSL5

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

cell fate specification
negative regulation of microtubule depolymerization
pattern specification process
cell proliferation
Wnt signaling pathway
cell migration
negative regulation of catenin import into nucleus
regulation of cell differentiation
positive regulation of protein catabolic process
negative regulation of canonical Wnt signaling pathway

Function(s)

protein binding
beta-catenin binding
microtubule binding
gamma-catenin binding