Hs00380858_cn

• Gene Symbol: NFKB2
• Assay Reference Genome Location: Chr.10:102397588 on build GRCh38
• Cytoband: 10q24.32

Target Gene Details

• Entrez Gene ID: 4791
• Gene Name: nuclear factor kappa B subunit 2
• Gene Aliases: CVID10, H2TF1, LYT-10, LYT10, NF-kB2, p100, p49/p100, p52
• Location: Chr.10:102394110-102402529 on Build GRCh38
• Assay Gene Location: Within Exon 9

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NFKB2	NM_001077494.3	8	833	NP_001070962.1
	NM_001261403.2	7	928	NP_001248332.1
	NM_001288724.1	8	1127	NP_001275653.1
	NM_001322934.1	8	837	NP_001309863.1
	NM_001322935.1	8	1127	NP_001309864.1
	NM_002502.5	8	837	NP_002493.3
	XM_011539830.2	3	191	XP_011538132.1
	XM_011539831.2	3	188	XP_011538133.1
	XM_017016278.1	8	1122	XP_016871767.1
	AK292654.1	7	781
	BC002844.2	8	664	AAH02844.1
	BT009769.1	7	564	AAP88771.1
	S76638.1	8	814	AAB21124.1
	U09609.2	7	564	AAA21462.2
	X61498.1	8	727	CAA43715.1
	X61499.1	8	727	CAA43716.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1159761	Chr.10:102372778 - 102430809 on Build GRCh38	Deletion	CUEDC2 GBF1 PSD FBXL15 NFKB2
nsv526665	Chr.10:102363085 - 102397954 on Build GRCh38	Loss	GBF1 NFKB2
nsv525546	Chr.10:102380593 - 102415138 on Build GRCh38	Loss	GBF1 PSD NFKB2
nsv951006	Chr.10:102394644 - 102425743 on Build GRCh38	Deletion	CUEDC2 PSD FBXL15 NFKB2

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

Rel homology transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
follicular dendritic cell differentiation
germinal center formation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
inflammatory response
I-kappaB kinase/NF-kappaB signaling
aging
extracellular matrix organization
positive regulation of type I interferon production
response to lipopolysaccharide
response to cytokine
NIK/NF-kappaB signaling
innate immune response
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
spleen development
positive regulation of NF-kappaB transcription factor activity

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding