Hs00263712_cn

• Gene Symbol: TCF3
• Assay Reference Genome Location: Chr.19:1611009 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 6929
• Gene Name: transcription factor 3
• Gene Aliases: AGM8, E2A, E47, ITF1, TCF-3, VDIR, bHLHb21
• Location: Chr.19:1609290-1652590 on Build GRCh38
• Assay Gene Location: Within Exon 20

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TCF3	NM_001136139.2	19	2359	NP_001129611.1
	NM_003200.3	19	2732	NP_003191.1
	XM_006722852.3			XP_006722915.1
	XM_006722853.3			XP_006722916.1
	XM_006722855.3	20	2562	XP_006722918.1
	XM_006722856.3			XP_006722919.1
	XM_006722857.3	20	2560	XP_006722920.1
	XM_006722858.3			XP_006722921.1
	XM_011528215.2	18	4205	XP_011526517.1
	XM_011528216.2	19	2906	XP_011526518.1
	XM_011528217.2	19	2909	XP_011526519.1
	XM_011528219.2	19	2904	XP_011526521.1
	XM_011528220.2	19	2896	XP_011526522.1
	XM_011528221.2	19	2894	XP_011526523.1
	XM_011528223.2	19	2815	XP_011526525.1
	XM_011528225.2	19	2806	XP_011526527.1
	XM_011528226.2	19	2806	XP_011526528.1
	XM_011528227.2	17	2655	XP_011526529.1
	XM_017027177.1	20	2572	XP_016882666.1
	XM_017027178.1			XP_016882667.1
	XM_017027179.1	20	2560	XP_016882668.1
	XM_017027180.1	16	2833	XP_016882669.1
	XM_017027181.1	20	2484	XP_016882670.1
	XM_017027182.1	20	2474	XP_016882671.1
	XM_017027183.1			XP_016882672.1
	AK310998.1	2	440
	BC011665.2	16	2476	AAH11665.1
	M31523.1	18	2693	AAA61146.1
	X52078.1			CAA36297.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv32942	Chr.19:1320268 - 1999205 on Build GRCh38	Gain+Loss	SCAMP4 MEX3D RPS15 NDUFS7 PLK5 ADAMTSL5 TCF3 UQCR11 ATP8B3 APC2 ABHD17A MUM1 ONECUT3 C19orf25 MBD3 BTBD2 GAMT ADAT3 REEP6 CSNK1G2 PCSK4 REXO1 LOC100288123 CSNK1G2-AS1 DAZAP1 KLF16 MIR1909
nsv828379	Chr.19:1610817 - 1611355 on Build GRCh38	Gain	TCF3
nsv953942	Chr.19:1371602 - 2057401 on Build GRCh38	Deletion	SCAMP4 MEX3D RPS15 MKNK2 NDUFS7 PLK5 ADAMTSL5 TCF3 UQCR11 ATP8B3 APC2 ABHD17A MUM1 ONECUT3 C19orf25 MBD3 BTBD2 GAMT ADAT3 REEP6 CSNK1G2 PCSK4 REXO1 LOC100288123 CSNK1G2-AS1 DAZAP1 KLF16 MIR1909

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

basic helix-loop-helix transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
B cell lineage commitment
transcription, DNA-templated
regulation of transcription, DNA-templated
B cell differentiation
immunoglobulin V(D)J recombination
positive regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of muscle cell differentiation

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
transcription factor binding
mitogen-activated protein kinase kinase kinase binding
enhancer binding
protein homodimerization activity
bHLH transcription factor binding
protein heterodimerization activity
repressing transcription factor binding
vitamin D response element binding
E-box binding