Hs00174719_cn

• Gene Symbol: BECN1
• Assay Reference Genome Location: Chr.17:42811821 on build GRCh38
• Cytoband: 17q21.31

Target Gene Details

• Entrez Gene ID: 8678
• Gene Name: beclin 1
• Gene Aliases: ATG6, VPS30, beclin1
• Location: Chr.17:42810132-42824316 on Build GRCh38
• Assay Gene Location: Overlaps Intron 11 - Exon 12

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
BECN1	NM_001313998.1			NP_001300927.1
	NM_001313999.1			NP_001300928.1
	NM_001314000.1			NP_001300929.1
	NM_003766.4			NP_003757.1
	XM_005257759.2			XP_005257816.1
	XM_005257760.3			XP_005257817.1
	XM_011525421.2			XP_011523723.1
	XM_017025262.1			XP_016880751.1
	XM_017025263.1			XP_016880752.1
	XM_017025264.1			XP_016880753.1
	AF077301.1			AAC68653.1
	AF139131.1			AAD27650.1
	AK223411.1			BAD97131.1
	AK298619.1
	AK299616.1
	AK312651.1
	BC010276.1			AAH10276.1
	BX647788.1	8	3905
	KC776730.1
	L38932.1			AAB59573.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv833450	Chr.17:42660985 - 42825144 on Build GRCh38	Loss	RAMP2 WNK4 CNTNAP1 COA3 VPS25 PLEKHH3 RAMP2-AS1 CCR10 MIR6781 MIR6780A TUBG2 BECN1 CNTD1 EZH1

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protease inhibitor

Gene Ontology Categories:

Process(es)

autophagosome assembly
cytokinesis
response to hypoxia
autophagy
apoptotic process
cellular defense response
cellular response to nitrogen starvation
lysosome organization
mitotic metaphase plate congression
negative regulation of cell proliferation
positive regulation of autophagy
positive regulation of phosphatidylinositol 3-kinase signaling
macroautophagy
positive regulation of macroautophagy
CVT pathway
regulation of cytokinesis
receptor catabolic process
response to vitamin E
cellular response to glucose starvation
response to drug
negative regulation of apoptotic process
engulfment of apoptotic cell
nucleophagy
late endosome to vacuole transport
neuron development
beta-amyloid metabolic process
regulation of catalytic activity
defense response to virus
negative regulation of cell death
cellular response to aluminum ion
cellular response to epidermal growth factor stimulus
mitophagy in response to mitochondrial depolarization
positive regulation of attachment of mitotic spindle microtubules to kinetochore
positive regulation of mitophagy
negative regulation of reactive oxygen species metabolic process

Function(s)

protein binding
ubiquitin protein ligase binding
phosphatidylinositol 3-kinase binding