Hs00132858_cn

• Gene Symbol: PRODH
• Assay Reference Genome Location: Chr.22:18925129 on build GRCh38
• Cytoband: 22q11.21

Target Gene Details

• Entrez Gene ID: 5625
• Gene Name: proline dehydrogenase 1
• Gene Aliases: HSPOX2, PIG6, POX, PRODH1, PRODH2, TP53I6
• Location: Chr.22:18912774-18936553 on Build GRCh38
• Assay Gene Location: Within Exon 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PRODH	NM_001195226.1	4	378	NP_001182155.1
	NM_016335.4	5	793	NP_057419.4
	BC118597.1	4	378

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv588196	Chr.22:18913491 - 18953944 on Build GRCh38	Gain	PRODH
esv32687	Chr.22:18158909 - 19022965 on Build GRCh38	Gain+Loss	LOC642643 DGCR9 LOC100996415 RIMBP3 LOC102725072 DGCR10 PI4KAP1 DGCR5 LOC100996432 PRODH FAM230A USP18 DGCR6 LOC100996401 TMEM191B LOC729461 GGT3P
nsv588203	Chr.22:18925165 - 19020595 on Build GRCh38	Gain+Loss	DGCR9 DGCR5 PRODH
nsv953020	Chr.22:18899988 - 18938787 on Build GRCh38	Deletion	DGCR6 PRODH
dgv4473n100	Chr.22:18888903 - 19047585 on Build GRCh38	Gain+Loss	DGCR9 DGCR6 DGCR2 DGCR10 DGCR5 LOC100996432 PRODH DGCR11
esv3584483	Chr.22:18782908 - 19018612 on Build GRCh38	Gain	DGCR9 DGCR6 LOC102725072 DGCR5 LOC100996432 PRODH GGT3P
esv2751935	Chr.22:18149609 - 19042823 on Build GRCh38	Loss	LOC642643 DGCR9 LOC100996415 RIMBP3 LOC102725072 DGCR10 PI4KAP1 DGCR5 LOC100996432 PRODH FAM230A USP18 DGCR6 DGCR2 LOC100996401 TMEM191B LOC729461 GGT3P
dgv543n27	Chr.22:18890274 - 19046019 on Build GRCh38	Gain	DGCR9 DGCR6 DGCR2 DGCR10 DGCR5 LOC100996432 PRODH
nsv588155	Chr.22:18795358 - 19020595 on Build GRCh38	Gain	DGCR9 DGCR6 LOC102725072 DGCR5 LOC100996432 PRODH
nsv1063432	Chr.22:18902533 - 18929331 on Build GRCh38	Loss	DGCR6 PRODH
esv3893431	Chr.22:18874235 - 19031473 on Build GRCh38	Gain+Loss	DGCR9 DGCR6 DGCR10 DGCR5 LOC100996432 PRODH
nsv516997	Chr.22:18143870 - 19039100 on Build GRCh38	Gain+Loss	LOC642643 DGCR9 LOC100996415 RIMBP3 LOC102725072 DGCR10 PI4KAP1 DGCR5 LOC100996432 PRODH FAM230A USP18 DGCR6 DGCR2 LOC100996401 TMEM191B LOC729461 GGT3P
dgv1283e212	Chr.22:18166100 - 19017223 on Build GRCh38	Gain	LOC642643 LOC100996415 RIMBP3 LOC102725072 PI4KAP1 DGCR5 LOC100996432 PRODH FAM230A USP18 DGCR6 LOC100996401 TMEM191B LOC729461 GGT3P
dgv4476n100	Chr.22:18899376 - 19019471 on Build GRCh38	Gain	DGCR9 DGCR6 DGCR5 PRODH
dgv99e203	Chr.22:18173093 - 19019471 on Build GRCh38	Gain+Loss	LOC642643 DGCR9 LOC100996415 RIMBP3 LOC102725072 PI4KAP1 DGCR5 LOC100996432 PRODH FAM230A USP18 DGCR6 LOC100996401 TMEM191B LOC729461 GGT3P
nsv442503	Chr.22:18822597 - 19018611 on Build GRCh38	Gain	DGCR9 DGCR6 LOC102725072 DGCR5 LOC100996432 PRODH
esv2758824	Chr.22:18069029 - 19074200 on Build GRCh38	Gain+Loss	LOC642643 DGCR9 LOC100996415 RIMBP3 LOC102725072 DGCR10 PI4KAP1 DGCR5 LOC100996432 TUBA8 PRODH FAM230A PEX26 USP18 DGCR6 DGCR2 LOC100996401 TMEM191B LOC729461 GGT3P DGCR11
esv3893432	Chr.22:18750783 - 19029150 on Build GRCh38	Gain	LOC642643 DGCR9 DGCR6 LOC102725072 DGCR10 DGCR5 LOC100996432 PRODH GGT3P
dgv4466n100	Chr.22:18166204 - 19019471 on Build GRCh38	Gain+Loss	LOC642643 DGCR9 LOC100996415 RIMBP3 LOC102725072 PI4KAP1 DGCR5 LOC100996432 PRODH FAM230A USP18 DGCR6 LOC100996401 TMEM191B LOC729461 GGT3P
dgv173e55	Chr.22:18157533 - 19070277 on Build GRCh38	Gain	LOC642643 DGCR9 LOC100996415 RIMBP3 LOC102725072 DGCR10 PI4KAP1 DGCR5 LOC100996432 PRODH FAM230A USP18 DGCR6 DGCR2 LOC100996401 TMEM191B LOC729461 GGT3P DGCR11
dgv42e213	Chr.22:18888915 - 19019471 on Build GRCh38	Gain	DGCR9 DGCR6 DGCR5 LOC100996432 PRODH
dgv169n111	Chr.22:18745406 - 19019471 on Build GRCh38	Duplication	LOC642643 DGCR9 DGCR6 LOC102725072 DGCR5 LOC100996432 PRODH GGT3P
dgv7975n54	Chr.22:18901977 - 19029150 on Build GRCh38	Loss	DGCR9 DGCR6 DGCR10 DGCR5 PRODH
dgv4468n100	Chr.22:18760915 - 19019471 on Build GRCh38	Gain+Loss	DGCR9 DGCR6 LOC102725072 DGCR5 LOC100996432 PRODH GGT3P
esv3647249	Chr.22:18924644 - 19011486 on Build GRCh38	Loss	DGCR5 PRODH
nsv588201	Chr.22:18922407 - 18959084 on Build GRCh38	Loss	PRODH
dgv174e55	Chr.22:18903433 - 19050022 on Build GRCh38	Gain	DGCR9 DGCR6 DGCR2 DGCR10 DGCR5 PRODH DGCR11
esv3584485	Chr.22:18806434 - 18964032 on Build GRCh38	Gain	DGCR6 LOC102725072 LOC100996432 PRODH
nsv1067175	Chr.22:18822569 - 19046938 on Build GRCh38	Loss	DGCR9 DGCR6 DGCR2 LOC102725072 DGCR10 DGCR5 LOC100996432 PRODH DGCR11
nsv979632	Chr.22:18908034 - 18929580 on Build GRCh38	Duplication	DGCR6 PRODH
nsv1160726	Chr.22:18899868 - 19019471 on Build GRCh38	Duplication	DGCR9 DGCR6 DGCR5 PRODH
dgv7976n54	Chr.22:18903102 - 18988074 on Build GRCh38	Gain	DGCR6 DGCR5 PRODH
esv22247	Chr.22:18174171 - 18937942 on Build GRCh38	Gain+Loss	LOC642643 LOC100996415 RIMBP3 LOC102725072 PI4KAP1 LOC100996432 PRODH FAM230A USP18 DGCR6 LOC100996401 TMEM191B LOC729461 GGT3P
esv3575418	Chr.22:18161776 - 19963846 on Build GRCh38	Gain	DGCR9 TSSK2 HIRA SEPT5-GP1BB LOC100996415 UFD1L TBX1 MIR4761 PI4KAP1 DGCR5 LOC100996432 LINC00895 COMT FAM230A USP18 DGCR6 DGCR2 LOC100996401 SLC25A1 C22orf39 DGCR14 LOC729461 CLDN5 DGCR11 LOC642643 RIMBP3 LOC102725072 DGCR10 PRODH SEPT5 GNB1L GP1BB GSC2 TMEM191B MRPL40 CDC45 C22orf29 LINC01311 TXNRD2 CLTCL1 GGT3P

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

oxidase

Gene Ontology Categories:

Process(es)

proline metabolic process
proline catabolic process
intrinsic apoptotic signaling pathway in response to oxidative stress
proline catabolic process to glutamate
positive regulation of cell death
4-hydroxyproline catabolic process
oxidation-reduction process

Function(s)

proline dehydrogenase activity
FAD binding