Hs00122839_cn

• Gene Symbol: PRODH
• Assay Reference Genome Location: Chr.22:18922881 on build GRCh38
• Cytoband: 22q11.21

Target Gene Details

• Entrez Gene ID: 5625
• Gene Name: proline dehydrogenase 1
• Gene Aliases: HSPOX2, PIG6, POX, PRODH1, PRODH2, TP53I6
• Location: Chr.22:18912774-18936553 on Build GRCh38
• Assay Gene Location: Within Exon 7

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PRODH	NM_001195226.1	6	574	NP_001182155.1
	NM_016335.4	7	989	NP_057419.4
	BC118597.1	6	574
	CB216963.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv588196	Chr.22:18913491 - 18953944 on Build GRCh38	Gain	PRODH
esv32687	Chr.22:18158909 - 19022965 on Build GRCh38	Gain+Loss	LOC100996415 TMEM191B FAM230A LOC729461 DGCR9 LOC642643 RIMBP3 USP18 GGT3P DGCR10 DGCR6 PRODH LOC100996401 PI4KAP1 LOC100996432 DGCR5 LOC102725072
nsv953020	Chr.22:18899988 - 18938787 on Build GRCh38	Deletion	DGCR6 PRODH
dgv4473n100	Chr.22:18888903 - 19047585 on Build GRCh38	Gain+Loss	DGCR6 PRODH DGCR9 LOC100996432 DGCR5 DGCR11 DGCR10 DGCR2
esv3584483	Chr.22:18782908 - 19018612 on Build GRCh38	Gain	DGCR6 PRODH DGCR9 LOC100996432 DGCR5 LOC102725072 GGT3P
esv2751935	Chr.22:18149609 - 19042823 on Build GRCh38	Loss	LOC100996415 TMEM191B FAM230A LOC729461 DGCR9 LOC642643 RIMBP3 USP18 GGT3P DGCR10 DGCR2 DGCR6 PRODH LOC100996401 PI4KAP1 LOC100996432 DGCR5 LOC102725072
dgv543n27	Chr.22:18890274 - 19046019 on Build GRCh38	Gain	DGCR6 PRODH DGCR9 LOC100996432 DGCR5 DGCR10 DGCR2
nsv588155	Chr.22:18795358 - 19020595 on Build GRCh38	Gain	DGCR6 PRODH DGCR9 LOC100996432 DGCR5 LOC102725072
nsv1063432	Chr.22:18902533 - 18929331 on Build GRCh38	Loss	DGCR6 PRODH
esv3893431	Chr.22:18874235 - 19031473 on Build GRCh38	Gain+Loss	DGCR6 PRODH DGCR9 LOC100996432 DGCR5 DGCR10
nsv516997	Chr.22:18143870 - 19039100 on Build GRCh38	Gain+Loss	LOC100996415 TMEM191B FAM230A LOC729461 DGCR9 LOC642643 RIMBP3 USP18 GGT3P DGCR10 DGCR2 DGCR6 PRODH LOC100996401 PI4KAP1 LOC100996432 DGCR5 LOC102725072
dgv1283e212	Chr.22:18166100 - 19017223 on Build GRCh38	Gain	LOC100996415 TMEM191B FAM230A LOC729461 LOC642643 RIMBP3 USP18 GGT3P DGCR6 PRODH LOC100996401 PI4KAP1 LOC100996432 DGCR5 LOC102725072
dgv4476n100	Chr.22:18899376 - 19019471 on Build GRCh38	Gain	DGCR6 PRODH DGCR9 DGCR5
dgv99e203	Chr.22:18173093 - 19019471 on Build GRCh38	Gain+Loss	LOC100996415 TMEM191B FAM230A LOC729461 DGCR9 LOC642643 RIMBP3 USP18 GGT3P DGCR6 PRODH LOC100996401 PI4KAP1 LOC100996432 DGCR5 LOC102725072
nsv442503	Chr.22:18822597 - 19018611 on Build GRCh38	Gain	DGCR6 PRODH DGCR9 LOC100996432 DGCR5 LOC102725072
esv2758824	Chr.22:18069029 - 19074200 on Build GRCh38	Gain+Loss	LOC100996415 TMEM191B FAM230A LOC729461 DGCR9 LOC642643 RIMBP3 TUBA8 USP18 GGT3P DGCR10 DGCR2 DGCR6 PRODH PEX26 LOC100996401 PI4KAP1 LOC100996432 DGCR5 LOC102725072 DGCR11
esv3893432	Chr.22:18750783 - 19029150 on Build GRCh38	Gain	DGCR6 PRODH DGCR9 LOC100996432 LOC642643 DGCR5 LOC102725072 GGT3P DGCR10
dgv4466n100	Chr.22:18166204 - 19019471 on Build GRCh38	Gain+Loss	LOC100996415 TMEM191B FAM230A LOC729461 DGCR9 LOC642643 RIMBP3 USP18 GGT3P DGCR6 PRODH LOC100996401 PI4KAP1 LOC100996432 DGCR5 LOC102725072
dgv173e55	Chr.22:18157533 - 19070277 on Build GRCh38	Gain	LOC100996415 TMEM191B FAM230A LOC729461 DGCR9 LOC642643 RIMBP3 USP18 GGT3P DGCR10 DGCR2 DGCR6 PRODH LOC100996401 PI4KAP1 LOC100996432 DGCR5 LOC102725072 DGCR11
dgv42e213	Chr.22:18888915 - 19019471 on Build GRCh38	Gain	DGCR6 PRODH DGCR9 LOC100996432 DGCR5
dgv169n111	Chr.22:18745406 - 19019471 on Build GRCh38	Duplication	DGCR6 PRODH DGCR9 LOC100996432 LOC642643 DGCR5 LOC102725072 GGT3P
dgv7975n54	Chr.22:18901977 - 19029150 on Build GRCh38	Loss	DGCR6 PRODH DGCR9 DGCR5 DGCR10
dgv4468n100	Chr.22:18760915 - 19019471 on Build GRCh38	Gain+Loss	DGCR6 PRODH DGCR9 LOC100996432 DGCR5 LOC102725072 GGT3P
nsv588201	Chr.22:18922407 - 18959084 on Build GRCh38	Loss	PRODH
dgv174e55	Chr.22:18903433 - 19050022 on Build GRCh38	Gain	DGCR6 PRODH DGCR9 DGCR5 DGCR11 DGCR10 DGCR2
esv3584485	Chr.22:18806434 - 18964032 on Build GRCh38	Gain	DGCR6 PRODH LOC100996432 LOC102725072
nsv1067175	Chr.22:18822569 - 19046938 on Build GRCh38	Loss	DGCR6 PRODH DGCR9 LOC100996432 DGCR5 LOC102725072 DGCR11 DGCR10 DGCR2
nsv979632	Chr.22:18908034 - 18929580 on Build GRCh38	Duplication	DGCR6 PRODH
nsv1160726	Chr.22:18899868 - 19019471 on Build GRCh38	Duplication	DGCR6 PRODH DGCR9 DGCR5
dgv7976n54	Chr.22:18903102 - 18988074 on Build GRCh38	Gain	DGCR6 PRODH DGCR5
esv22247	Chr.22:18174171 - 18937942 on Build GRCh38	Gain+Loss	LOC100996415 TMEM191B FAM230A LOC729461 LOC642643 RIMBP3 USP18 GGT3P DGCR6 PRODH LOC100996401 PI4KAP1 LOC100996432 LOC102725072
esv3575418	Chr.22:18161776 - 19963846 on Build GRCh38	Gain	LOC100996415 TMEM191B LINC01311 TBX1 COMT LOC642643 CDC45 RIMBP3 DGCR2 GNB1L SEPT5 CLDN5 PI4KAP1 GSC2 DGCR5 DGCR14 SEPT5-GP1BB LINC00895 FAM230A C22orf39 C22orf29 HIRA LOC729461 DGCR9 UFD1L CLTCL1 USP18 GGT3P DGCR10 DGCR6 GP1BB MRPL40 PRODH TSSK2 LOC100996401 SLC25A1 LOC100996432 LOC102725072 DGCR11 TXNRD2 MIR4761

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

oxidase

Gene Ontology Categories:

Process(es)

proline metabolic process
proline catabolic process
intrinsic apoptotic signaling pathway in response to oxidative stress
proline catabolic process to glutamate
positive regulation of cell death
4-hydroxyproline catabolic process
oxidation-reduction process

Function(s)

proline dehydrogenase activity
FAD binding