Hs00056800_cn

• Gene Symbol: PRODH
• Assay Reference Genome Location: Chr.22:18913294 on build GRCh38
• Cytoband: 22q11.21

Target Gene Details

• Entrez Gene ID: 5625
• Gene Name: proline dehydrogenase 1
• Gene Aliases: HSPOX2, PIG6, POX, PRODH1, PRODH2, TP53I6
• Location: Chr.22:18912774-18936553 on Build GRCh38
• Assay Gene Location: Within Exon 15

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PRODH	NM_001195226.1	14	1473	NP_001182155.1
	NM_016335.4	15	1888	NP_057419.4
	AA322439.1
	BC118597.1	14	1473

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv32687	Chr.22:18158909 - 19022965 on Build GRCh38	Gain+Loss	LOC729461 FAM230A LOC102725072 DGCR5 DGCR9 LOC100996401 TMEM191B PRODH DGCR10 RIMBP3 USP18 LOC100996415 GGT3P DGCR6 LOC642643 LOC100996432 PI4KAP1
dgv4474n100	Chr.22:18888903 - 19052558 on Build GRCh38	Gain	DGCR5 DGCR9 DGCR11 PRODH DGCR6 DGCR10 LOC100996432 DGCR2
nsv953020	Chr.22:18899988 - 18938787 on Build GRCh38	Deletion	PRODH DGCR6
esv3584483	Chr.22:18782908 - 19018612 on Build GRCh38	Gain	LOC102725072 DGCR5 DGCR9 GGT3P PRODH DGCR6 LOC100996432
esv2751935	Chr.22:18149609 - 19042823 on Build GRCh38	Loss	LOC729461 FAM230A LOC102725072 DGCR5 DGCR9 LOC100996401 TMEM191B PRODH DGCR10 DGCR2 RIMBP3 USP18 LOC100996415 GGT3P DGCR6 LOC642643 LOC100996432 PI4KAP1
nsv588155	Chr.22:18795358 - 19020595 on Build GRCh38	Gain	LOC102725072 DGCR5 DGCR9 PRODH DGCR6 LOC100996432
dgv543n27	Chr.22:18890274 - 19046019 on Build GRCh38	Gain	DGCR5 DGCR9 PRODH DGCR6 DGCR10 LOC100996432 DGCR2
nsv1063432	Chr.22:18902533 - 18929331 on Build GRCh38	Loss	PRODH DGCR6
esv3893431	Chr.22:18874235 - 19031473 on Build GRCh38	Gain+Loss	DGCR5 DGCR9 PRODH DGCR6 DGCR10 LOC100996432
nsv516997	Chr.22:18143870 - 19039100 on Build GRCh38	Gain+Loss	LOC729461 FAM230A LOC102725072 DGCR5 DGCR9 LOC100996401 TMEM191B PRODH DGCR10 DGCR2 RIMBP3 USP18 LOC100996415 GGT3P DGCR6 LOC642643 LOC100996432 PI4KAP1
dgv1283e212	Chr.22:18166100 - 19017223 on Build GRCh38	Gain	LOC729461 FAM230A LOC102725072 DGCR5 LOC100996401 TMEM191B PRODH RIMBP3 USP18 LOC100996415 GGT3P DGCR6 LOC642643 LOC100996432 PI4KAP1
dgv99e203	Chr.22:18173093 - 19019471 on Build GRCh38	Gain+Loss	LOC729461 FAM230A LOC102725072 DGCR5 DGCR9 LOC100996401 TMEM191B PRODH RIMBP3 USP18 LOC100996415 GGT3P DGCR6 LOC642643 LOC100996432 PI4KAP1
dgv4476n100	Chr.22:18899376 - 19019471 on Build GRCh38	Gain	DGCR5 DGCR9 PRODH DGCR6
nsv442503	Chr.22:18822597 - 19018611 on Build GRCh38	Gain	LOC102725072 DGCR5 DGCR9 PRODH DGCR6 LOC100996432
esv2758824	Chr.22:18069029 - 19074200 on Build GRCh38	Gain+Loss	LOC729461 FAM230A LOC102725072 DGCR5 DGCR9 LOC100996401 TMEM191B PRODH DGCR10 DGCR2 RIMBP3 PEX26 USP18 LOC100996415 DGCR11 GGT3P TUBA8 DGCR6 LOC642643 LOC100996432 PI4KAP1
esv3893432	Chr.22:18750783 - 19029150 on Build GRCh38	Gain	LOC102725072 DGCR5 DGCR9 GGT3P PRODH DGCR6 LOC642643 DGCR10 LOC100996432
dgv4466n100	Chr.22:18166204 - 19019471 on Build GRCh38	Gain+Loss	LOC729461 FAM230A LOC102725072 DGCR5 DGCR9 LOC100996401 TMEM191B PRODH RIMBP3 USP18 LOC100996415 GGT3P DGCR6 LOC642643 LOC100996432 PI4KAP1
dgv173e55	Chr.22:18157533 - 19070277 on Build GRCh38	Gain	LOC729461 FAM230A LOC102725072 DGCR5 DGCR9 LOC100996401 TMEM191B PRODH DGCR10 DGCR2 RIMBP3 USP18 LOC100996415 DGCR11 GGT3P DGCR6 LOC642643 LOC100996432 PI4KAP1
dgv42e213	Chr.22:18888915 - 19019471 on Build GRCh38	Gain	DGCR5 DGCR9 PRODH DGCR6 LOC100996432
dgv169n111	Chr.22:18745406 - 19019471 on Build GRCh38	Duplication	LOC102725072 DGCR5 DGCR9 GGT3P PRODH DGCR6 LOC642643 LOC100996432
dgv4468n100	Chr.22:18760915 - 19019471 on Build GRCh38	Gain+Loss	LOC102725072 DGCR5 DGCR9 GGT3P PRODH DGCR6 LOC100996432
dgv7975n54	Chr.22:18901977 - 19029150 on Build GRCh38	Loss	DGCR5 DGCR9 PRODH DGCR6 DGCR10
dgv174e55	Chr.22:18903433 - 19050022 on Build GRCh38	Gain	DGCR5 DGCR9 DGCR11 PRODH DGCR6 DGCR10 DGCR2
esv3584485	Chr.22:18806434 - 18964032 on Build GRCh38	Gain	LOC102725072 PRODH DGCR6 LOC100996432
nsv1067175	Chr.22:18822569 - 19046938 on Build GRCh38	Loss	LOC102725072 DGCR5 DGCR9 DGCR11 PRODH DGCR6 DGCR10 LOC100996432 DGCR2
nsv979632	Chr.22:18908034 - 18929580 on Build GRCh38	Duplication	PRODH DGCR6
nsv1160726	Chr.22:18899868 - 19019471 on Build GRCh38	Duplication	DGCR5 DGCR9 PRODH DGCR6
esv22247	Chr.22:18174171 - 18937942 on Build GRCh38	Gain+Loss	LOC729461 FAM230A LOC102725072 LOC100996401 TMEM191B PRODH RIMBP3 USP18 LOC100996415 GGT3P DGCR6 LOC642643 LOC100996432 PI4KAP1
dgv7976n54	Chr.22:18903102 - 18988074 on Build GRCh38	Gain	DGCR5 PRODH DGCR6
esv3575418	Chr.22:18161776 - 19963846 on Build GRCh38	Gain	LINC01311 FAM230A LOC102725072 DGCR5 DGCR9 TXNRD2 TBX1 GSC2 PRODH GNB1L COMT LINC00895 C22orf39 DGCR2 RIMBP3 LOC100996415 DGCR14 TSSK2 SLC25A1 GGT3P GP1BB UFD1L PI4KAP1 LOC729461 SEPT5 CLDN5 SEPT5-GP1BB C22orf29 LOC100996401 TMEM191B DGCR10 CLTCL1 MIR4761 USP18 HIRA CDC45 DGCR11 DGCR6 LOC642643 LOC100996432 MRPL40

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

oxidase

Gene Ontology Categories:

Process(es)

proline metabolic process
proline catabolic process
intrinsic apoptotic signaling pathway in response to oxidative stress
proline catabolic process to glutamate
positive regulation of cell death
4-hydroxyproline catabolic process
oxidation-reduction process

Function(s)

proline dehydrogenase activity
FAD binding