Hs06641715_cn

• Gene Symbol: ATR
• Assay Reference Genome Location: Chr.3:142486292 on build GRCh38
• Cytoband: 3q23

Target Gene Details

• Entrez Gene ID: 545
• Gene Name: ATR serine/threonine kinase
• Gene Aliases: FCTCS, FRP1, MEC1, SCKL, SCKL1
• Location: Chr.3:142449235-142578826 on Build GRCh38
• Assay Gene Location: Within Intron 35

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ATR	NM_001184.3			NP_001175.2
	XM_011512924.1			XP_011511226.1
	XM_011512925.1			XP_011511227.1
	XM_011512926.2			XP_011511228.1
	XM_017006643.1			XP_016862132.1
	U49844.1			AAC50405.1
	U76308.1			AAC50929.1
	Y09077.1			CAA70298.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv523945	Chr.3:142214807 - 142500700 on Build GRCh38	Gain	XRN1 GK5 ATR
nsv528954	Chr.3:142445175 - 142500700 on Build GRCh38	Loss	XRN1 ATR

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase, protein modifying enzyme

Gene Ontology Categories:

Process(es)

DNA damage checkpoint
DNA replication
DNA repair
cellular response to DNA damage stimulus
cell cycle
multicellular organism development
negative regulation of DNA replication
peptidyl-serine phosphorylation
positive regulation of telomere maintenance via telomerase
cellular response to UV
interstrand cross-link repair
response to drug
positive regulation of DNA damage response, signal transduction by p53 class mediator
protein autophosphorylation
protein localization to chromosome, telomeric region
cellular response to gamma radiation
replicative senescence
establishment of RNA localization to telomere
establishment of macromolecular complex localization to telomere
regulation of cellular response to heat
regulation of signal transduction by p53 class mediator
positive regulation of telomerase catalytic core complex assembly

Function(s)

DNA binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
MutLalpha complex binding
MutSalpha complex binding