Hs06249219_cn

• Gene Symbol: NRG1
• Assay Reference Genome Location: Chr.8:31662894 on build GRCh38
• Cytoband: 8p12

Target Gene Details

• Entrez Gene ID: 3084
• Gene Name: neuregulin 1
• Gene Aliases: ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF
• Location: Chr.8:31639222-32771716 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NRG1	NM_001159995.2			NP_001153467.1
	NM_001159999.2			NP_001153471.1
	NM_001160001.2			NP_001153473.1
	NM_001322201.1			NP_001309130.1
	NM_001322202.1			NP_001309131.1
	NM_013962.2			NP_039256.2
	XM_011544512.2			XP_011542814.1
	XM_017013365.1			XP_016868854.1
	XM_017013366.1			XP_016868855.1
	XM_017013367.1			XP_016868856.1
	XM_017013371.1			XP_016868860.1
	XM_017013372.1			XP_016868861.1
	CN603652.1
	CN603654.1
	EF372273.1
	EF372274.1
	EF372275.1
	EF372276.1
	EF372277.1
	EF517295.1
	EF517296.1
	EF517297.1
	GQ983557.1
	GQ983558.1
	L12260.1			AAB59622.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3891380	Chr.8:31278415 - 31706814 on Build GRCh38	Gain	NRG1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

growth factor

Gene Ontology Categories:

Process(es)

MAPK cascade
activation of MAPK activity
cell morphogenesis
startle response
cardiac conduction system development
ventricular trabecula myocardium morphogenesis
cell communication
activation of transmembrane receptor protein tyrosine kinase activity
nervous system development
synapse assembly
peripheral nervous system development
locomotory behavior
regulation of blood pressure
positive regulation of cell proliferation
embryo development
neural crest cell development
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
glucose transport
peptidyl-tyrosine phosphorylation
glial cell fate commitment
chemorepulsion involved in interneuron migration from the subpallium to the cortex
mammary gland development
positive regulation of myelination
activation of protein kinase B activity
intracellular signal transduction
ERBB signaling pathway
ERBB2 signaling pathway
wound healing
negative regulation of protein catabolic process
myelination
regulation of protein homodimerization activity
regulation of protein heterodimerization activity
positive regulation of GTPase activity
neurotransmitter receptor metabolic process
positive regulation of axon extension
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of Ras protein signal transduction
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
neuron fate commitment
oligodendrocyte differentiation
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of secretion
positive regulation of striated muscle cell differentiation
positive regulation of protein kinase B signaling
cardiac muscle cell differentiation
cardiac muscle cell myoblast differentiation
endocardial cell differentiation
positive regulation of dendritic spine development
positive regulation of calcineurin-NFAT signaling cascade
positive regulation of protein targeting to mitochondrion
positive regulation of protein localization to cell surface
regulation of cell motility
positive regulation of cardiac muscle cell differentiation
negative regulation of neuron migration

Function(s)

transcription cofactor activity
protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
cytokine activity
ErbB-2 class receptor binding
integrin binding
growth factor activity
transmembrane receptor protein tyrosine kinase activator activity
receptor tyrosine kinase binding
ErbB-3 class receptor binding
chemorepellent activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity