Hs06074790_cn

• Gene Symbol: F2R
• Assay Reference Genome Location: Chr.5:76725718 on build GRCh38
• Cytoband: 5q13.3

Target Gene Details

• Entrez Gene ID: 2149
• Gene Name: coagulation factor II thrombin receptor
• Gene Aliases: CF2R, HTR, PAR-1, PAR1, TR
• Location: Chr.5:76716043-76735780 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
F2R	NM_001311313.1			NP_001298242.1
	NM_001992.4			NP_001983.2
	AK297131.1
	AK308169.1
	AK314202.1
	BC002464.2			AAH02464.1
	BC051909.1			AAH51909.1
	BT007279.1			AAP35943.1
	DA799420.1
	M62424.1			AAA36743.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1035135	Chr.5:76631202 - 76796233 on Build GRCh38	Gain	NCRUPAR F2R IQGAP2

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

G-protein coupled receptor

Gene Ontology Categories:

Process(es)

activation of MAPKK activity
connective tissue replacement involved in inflammatory response wound healing
negative regulation of glomerular filtration
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
protein kinase C-activating G-protein coupled receptor signaling pathway
tyrosine phosphorylation of STAT protein
STAT protein import into nucleus
establishment of synaptic specificity at neuromuscular junction
blood coagulation
positive regulation of cell proliferation
negative regulation of cell proliferation
response to wounding
anatomical structure morphogenesis
positive regulation of phosphatidylinositol 3-kinase signaling
platelet activation
regulation of blood coagulation
positive regulation of blood coagulation
positive regulation of cell migration
response to lipopolysaccharide
regulation of interleukin-1 beta production
positive regulation of collagen biosynthetic process
positive regulation of Rho protein signal transduction
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
positive regulation of transcription, DNA-templated
positive regulation of vasoconstriction
positive regulation of smooth muscle contraction
positive regulation of JAK-STAT cascade
homeostasis of number of cells within a tissue
release of sequestered calcium ion into cytosol
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
positive regulation of calcium ion transport
regulation of sensory perception of pain
platelet dense granule organization
positive regulation of ERK1 and ERK2 cascade
thrombin receptor signaling pathway
negative regulation of renin secretion into blood stream
positive regulation of interleukin-8 secretion
positive regulation of interleukin-6 secretion

Function(s)

G-protein alpha-subunit binding
G-protein coupled receptor activity
receptor binding
protein binding
thrombin receptor activity
G-protein beta-subunit binding