Hs03976661_cn

• Gene Symbol: SERPINF2
• Assay Reference Genome Location: Chr.17:1749938 on build GRCh38
• Cytoband: 17p13.3

Target Gene Details

• Entrez Gene ID: 5345
• Gene Name: serpin family F member 2
• Gene Aliases: A2AP, AAP, ALPHA-2-PI, API, PLI
• Location: Chr.17:1742808-1755265 on Build GRCh38
• Assay Gene Location: Within Intron 10

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SERPINF2	NM_000934.3			NP_000925.2
	NM_001165920.1			NP_001159392.1
	NM_001165921.1			NP_001159393.1
	XM_005256701.4			XP_005256758.2
	XM_017024765.1			XP_016880254.1
	AK303763.1
	BC031592.1			AAH31592.1
	D00116.1			BAA00070.1
	D00174.1			BAA00124.1
	J02654.1			AAA35543.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv9490	Chr.17:1653428 - 1828993 on Build GRCh38	Loss	WDR81 SMYD4 PRPF8 MIR22 SERPINF1 TLCD2 SERPINF2 MIR22HG
nsv1065585	Chr.17:1733183 - 1918769 on Build GRCh38	Gain	WDR81 SMYD4 RPA1 SERPINF1 SERPINF2
nsv1946	Chr.17:1717490 - 1781570 on Build GRCh38	Insertion	WDR81 SMYD4 SERPINF1 SERPINF2
nsv516886	Chr.17:1708905 - 1754359 on Build GRCh38	Loss	WDR81 MIR22 TLCD2 SERPINF2 MIR22HG
nsv833335	Chr.17:1713955 - 1827844 on Build GRCh38	Gain+Loss	WDR81 SMYD4 MIR22 SERPINF1 SERPINF2 MIR22HG

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protease inhibitor

Gene Ontology Categories:

Process(es)

regulation of blood vessel size by renin-angiotensin
platelet degranulation
acute-phase response
response to organic substance
negative regulation of plasminogen activation
negative regulation of endopeptidase activity
collagen fibril organization
positive regulation of collagen biosynthetic process
fibrinolysis
positive regulation of cell differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
blood vessel morphogenesis
positive regulation of smooth muscle cell proliferation
positive regulation of stress fiber assembly
negative regulation of fibrinolysis
positive regulation of ERK1 and ERK2 cascade
positive regulation of transforming growth factor beta production
positive regulation of cell-cell adhesion mediated by cadherin

Function(s)

protease binding
endopeptidase inhibitor activity
serine-type endopeptidase inhibitor activity
protein binding
protein homodimerization activity