Hs03969994_cn

• Gene Symbol: ALOX12B
• Assay Reference Genome Location: Chr.17:8074826 on build GRCh38
• Cytoband: 17p13.1

Target Gene Details

• Entrez Gene ID: 242
• Gene Name: arachidonate 12-lipoxygenase, 12R type
• Gene Aliases: 12R-LOX, ARCI2
• Location: Chr.17:8072636-8087703 on Build GRCh38
• Assay Gene Location: Within Intron 12

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ALOX12B	NM_001139.2			NP_001130.1
	AF038461.1			AAC39770.1
	AF059250.1			AAC79680.1
	BC041058.1			AAH41058.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv953825	Chr.17:8061683 - 8088382 on Build GRCh38	Deletion	LOC105371518 MIR4314 ALOX12B
nsv833352	Chr.17:8029719 - 8187575 on Build GRCh38	Loss	HES7 ALOXE3 VAMP2 MIR4314 SNORD118 TMEM107 MIR6883 PER1 ALOX15B LOC105371518 MIR4521 TRG-GCC2-6 ALOX12B

More Information

Additional Information:

For this assay, SNP(s) [rs73239937] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

oxygenase

Gene Ontology Categories:

Process(es)

protein lipidation
sphingolipid metabolic process
positive regulation of gene expression
arachidonic acid metabolic process
lipoxygenase pathway
positive regulation of MAPK cascade
linoleic acid metabolic process
ceramide biosynthetic process
hepoxilin biosynthetic process
oxidation-reduction process
establishment of skin barrier
positive regulation of mucus secretion

Function(s)

arachidonate 12-lipoxygenase activity
iron ion binding
protein binding
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
linoleate 9S-lipoxygenase activity